KLH-conjugated synthetic peptide between 251-279 amino acids from the Central region of human WHSC2.
Purification
Purified through a protein A column, followed by peptide affinity purification.
Isotype
IgG
Tested Application
WB
Uniprotkb
Q9H3P2 (UniProt, ExPASy)
Availability
Shipped within 5-10 working days.
Target
WHSC2
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Reactivity
Human
uniprot enrty name
NELFA_HUMAN
Note
This product is for research use only.
Clonality
polyclonal
Buffer
PBS containing 0.09% sodium azide.
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Description
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
Reviews of Wolf-Hirschhorn Syndrome Candidate 2 Protein (WHSC2) Antibody