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Home / Primary Antibodies

SARS virus Sn Antibody

SKU : BHA14445874

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Abbexa LTD

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Mfr.No.	abx032683
Conjugate	Unconjugated
Uniprot	Q6QU82, Q7T696, Q7TA19, Q7TFA2, Q7TFB1, Q80BV6
Kegg	vg:1489668
Host	Rabbit
Immunogen	KLH-conjugated synthetic peptide between 13-42 amino acids from the N-terminus of SARS CoV Spike protein.
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Isotype	IgG
Tested Application	WB
Uniprotkb	P59594 (UniProt, ExPASy)
Availability	Shipped within 5-10 working days.
Target	SARS virus Sn
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
uniprot enrty name	SPIKE_CVHSA
Note	This product is for research use only.
Clonality	polyclonal
Buffer	PBS containing 0.09% sodium azide.
Recommended Dilution	Optimal dilutions/concentrations should be determined by the end user.
Description	An outbreak of atypical pneumonia, referred to as severe acute respiratory syndrome (SARS) and first identified in Guangdong Province, China, has spread to several countries. The severity of this disease is such that the mortality rate appears to be ~3 to 6%. A number of laboratories worldwidehave undertaken the identification of the causative agent. The National Microbiology Laboratory in Canada obtained the Tor2 isolate from a patient in Toronto, and succeeded in growing a coronavirus-like agent in African Green Monkey Kidney (Vero E6) cells. This coronavirus has been named publicly by the World Health Organization and member laboratories as ?SARS virus? The SARS membrane proteins, including the major proteins S (Spike) and M (Membrane), are inserted into the endoplasmic reticulum Golgi intermediate compartment (ERGIC) while full length replicated RNA (+ strands) assemble with the N (nucleocapsid) protein. The virus then migrates through the Golgi complex and eventually exits the cell, likely by exocytosis. The site of viral attachment to the host cell resides within the S protein. Oligomeric spike (S) glycoproteins extend from SARS membranes. These integral membrane proteins assemble within the endoplasmic reticulum of infected cells and are subsequently endoproteolyzed in the Golgi, generating noncovalently associated S1 and S2 fragments. Once on the surface of infected cells and virions, peripheral S1 fragments bind carcinoembryonic antigen-related cell adhesion molecule (CEACAM) receptors, and this triggers membrane fusion reactions mediated by integral membrane S2 fragments.

SARS virus Sn Antibody

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SKU	Supplier No.	Size	Your price	Quantity
BHA14445874	abx032683	80 ul	$326.25		Add to Cart
BHA14445874	abx032683	400 ul	$551		Add to Cart

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