LC3 (APG8A / B) Antibody

Mfr.No.	abx029957
Conjugate	Unconjugated
Uniprot	Q6NW02
String	9606.ENSP00000268607
Host	Rabbit
Immunogen	KLH-conjugated synthetic peptide between 23-52 amino acids from human LC3.
Purification	Purified Rabbit Polyclonal Antibody.
Isotype	IgG
Tested Application	WB, IHC
Uniprotkb	Q9GZQ8 (UniProt, ExPASy)
Availability	Shipped within 5-10 working days.
Target	LC3 (APG8A/B)
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Reactivity	Human, Mouse, Rat
uniprot enrty name	MLP3B_HUMAN
Note	This product is for research use only.
Clonality	polyclonal
Buffer	PBS containing 0.09% sodium azide.
Recommended Dilution	Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user.
Description	Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a and MAP1LC3b are light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecules are cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.

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SKU	Supplier No.	Size	Your price	Quantity
BHA14477835	abx029957	80 ul	$326.25		Add to Cart
BHA14477835	abx029957	400 ul	$601.75		Add to Cart

LC3 (APG8A / B) Antibody

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