Aliquot and store in the dark at 2°C to 8°C. Avoid exposure to light.
Reactivity
Human
Molecular Weight
150 kDa
uniprot enrty name
ITA4_HUMAN
Note
This product is for research use only.
Clonality
monoclonal
Buffer
The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
Recommended Dilution
FCM: 20 µl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Description
The CD29 antigen, also known as the ß-1 subunit, is common to the VLA family of integrins. When acting as a matrix receptor, the CD49d antigen binds to CS-1, an alternatively spliced domain of fibronectin. When functioning as a cell receptor, the CD49d antigen binds to the vascular cell-adhesion molecule-1 (VCAM-1). The interaction between the CD49d antigen and VCAM-1 is known to play an important role in stabilizing the adhesion of lymphocytes to endothelial cells and in mediating B-lymphocyte precursor/bone marrow stromal cell adhesion. The CD49d antigen, when associated with the ß integrin, forms a lymphocyte homing receptor for Peyer's patch, binding tothe mucosal vascular addressin MAdCAM-1. The CD49d antigen is also involved in CD3-dependent CD4+ T-lymphocyte activation via its interaction with fibronectin.
Integrin Alpha 4 (ITGA4) Antibody (CF Blue)
Reviews of Integrin Alpha 4 (ITGA4) Antibody (CF Blue)