Aliquot and store in the dark at 2°C to 8°C. Avoid exposure to light.
Reactivity
Human
Molecular Weight
34 kDa
uniprot enrty name
CLM2_HUMAN
Note
This product is for research use only.
Clonality
monoclonal
Buffer
The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
Recommended Dilution
FCM: 20 µl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Description
The UP-H2 monoclonal antibody recognizes human IREM-2 (immune receptor expressed in monocytic derived cells) also known as LMIR6, and unofficially CD300E and CD300LE. It is a member of the CMRF-35 family. This 34 kDa Ig-like containing receptor is an activating receptor and through it’s charged residues in the cytokplasmic domain interacts with ITAM containing adaptor proteins like DAP12. Expression is found exclusively on monocytes and myeloid DC’s. Expression may be transient as differentiation of monocytes leads to down regulation of IREM-2 yet expression is found on mature DCs. It has been also noted that myeloid cell lines such as THP-1 and U937 do not express IREM-2.In vitro addition of UP-H2 antibody either soluble or crosslinked stimulates monocytes.
Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody (PerCP)
Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody (PerCP)
Reviews of Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody (PerCP)