B-Cell Receptor CD22 / SIGLEC2 (CD22) Antibody (PE)

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Mfr.No.	abx134566
Conjugate	PE
Host	Mouse
Form	Liquid
Immunogen	Hairy Cell Leukemia cells.
Purification	Affinity Chromatography
Isotype	IgG
Tested Application	FCM
Uniprotkb	P20273 (UniProt, ExPASy)
Gene Id	933
Availability	Shipped within 3-5 working days.
Target	B-Cell Receptor CD22 / SIGLEC2 (CD22)
Storage	Aliquot and store in the dark at 2°C to 8°C. Avoid exposure to light.
Reactivity	Human, Monkey
Molecular Weight	130-140 kDa
Note	This product is for research use only.
Clonality	monoclonal
Buffer	The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide
Recommended Dilution	FCM: 20 µl/1 million cells. Optimal dilutions/concentrations should be determined by the end user.
Description	The monoclonal antibody is directed against the CD22- antigen, which is expressed on human B lymphocytes. Normal T-cells, polymorph nuclear cells, monocytes and platelets were found to be negative. Cell lines SB, Raji and NALM-1 were found to be positive. Most CALLA-ALL were found to be positive. The reaction pattern to CLL and NHL is variable from weak to negative. PLL is clearly positive and Hairy Cell Leukaemia is very strong positive with this antibody. Reacts with the 130-140 kD glycosylated type I integral membrane protein present on the surface of mature B cells. CD22 is expressed in the cytoplasm of virtually all B cells except plasma cells. CD45RO antigen on T cells and CD75 antigen on B cells have been identified as ligands for CD22. CD22 has been reported to participate in B-cell activation and also as an adhesion molecule. Although the immunobiology of this antigen has not been fully elucidated, reports indicate that ligation of CD22 induces constitutive internalization of the molecule followed by complete degradation.

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SKU	Supplier No.	Size	Your price	Quantity
BHA144135481	abx134566	50 Assays	$362.50		Add to Cart
BHA144135481	abx134566	100 Assays	$464		Add to Cart

B-Cell Receptor CD22 / SIGLEC2 (CD22) Antibody (PE)

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