Purified recombinant fragment of human APOA5 (AA: 20-363) expressed in E. Coli.
Purification
Purified from ascites by Protein G chromatography.
Isotype
IgG
Tested Application
ELISA, WB
Uniprotkb
Q6Q788 (UniProt, ExPASy)
Gene Id
116519
Availability
Shipped within 5-10 working days.
Concentration
1 mg/ml
Target
Apoa5 (ab)
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Reactivity
Human
Molecular Weight
41 kDa
uniprot enrty name
APOA5_HUMAN
Note
This product is for research use only.
Clonality
monoclonal
Buffer
PBS, containing 0.03% sodium azide.
Recommended Dilution
ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Description
Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50–70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor- agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentration than other apolipoproteins.