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Home / Shanghai Model Organisms Center, Inc. / Animal Model / Humanized Knockins
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Humanized Knockins

Shanghai Model Organisms Center, Inc.

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Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

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  • hCD94

    hCD94

    hCD94

    • Nomenclature : C57BL/6JSmoc-Cd
    • KI/KO Gene : Klrd1
    • Strain : Embryo cryopres
    • Description : Model Descripti
    • Synonyms : CD94
  • hCLEC6A

    hCLEC6A

    hCLEC6A

    • Nomenclature : C57BL/6JSmoc-Cl
    • KI/KO Gene : Clec4n
    • Strain : Repository Live
    • Description : Model Descripti
    • Synonyms : Nkcl, Clec6a, C
  • hCLEC5A

    hCLEC5A

    hCLEC5A

    • Nomenclature : C57BL/6JSmoc-Cl
    • KI/KO Gene : Clec5a
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : Mdl1, Ly100, MD
  • hANGPTL4

    hANGPTL4

    hANGPTL4

    • Nomenclature : C57BL/6JSmoc-An
    • KI/KO Gene : Angptl4
    • Strain : Developing
    • Target : Metabolic Targe
    • Description : Model Descripti
  • hANGPTL3(3)

    hANGPTL3(3)

    hANGPTL3(3)

    • Nomenclature : C57BL/6JSmoc-An
    • KI/KO Gene : Angptl3
    • Research Application : Immunotherapy
    • Strain : Repository Live
    • Description : Model Descripti
  • hASGR1

    hASGR1

    hASGR1

    • Nomenclature : C57BL/6JSmoc-As
    • KI/KO Gene : Asgr1
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : Asgr, HL-1, ASG
  • hAPP

    hAPP

    hAPP

    • Nomenclature : C57BL/6JSmoc-Ap
    • KI/KO Gene : App
    • Strain : Developing
    • Target : Other Targets
    • Description : Model Descripti
  • hAPOE4

    hAPOE4

    hAPOE4

    • Nomenclature : C57BL/6JSmoc-Ap
    • KI/KO Gene : Apoe
    • Research Application : Cardiovascular
    • Strain : Repository Live
    • Target : Metabolic Targe
  • hBACE1

    hBACE1

    hBACE1

    • Nomenclature : C57BL/6JSmoc-Ba
    • KI/KO Gene : Bace1
    • Strain : Developing
    • Target : Other Targets
    • Description : Model Descripti
  • hPD-1(2)

    hPD-1(2)

    hPD-1(2)

    • Nomenclature : C57BL/6JSmoc-Pd
    • KI/KO Gene : Pdcd1
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : PD-1, Pdc1, Ly1
  • hPD-L1(BALB/c,2)

    hPD-L1(BALB/c,2)

    hPD-L1(BALB/c,2)

    • Nomenclature : BALB/cAnSmoc-Cd
    • KI/KO Gene : Cd274
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : B7h1, Pdl1, Pdc
  • hPSGL-1

    hPSGL-1

    hPSGL-1

    • Nomenclature : C57BL/6JSmoc-Se
    • KI/KO Gene : Selplg
    • Research Application : Immunotherapy
    • Strain : Embryo cryopres
    • Description : Model Descripti
  • hROR1

    hROR1

    hROR1

    • Nomenclature : C57BL/6JSmoc-Ro
    • KI/KO Gene : Ror1
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : Ntrkr1, 2810404
  • hRAMP3

    hRAMP3

    hRAMP3

    • Nomenclature : C57BL/6JSmoc-Ra
    • KI/KO Gene : Ramp3
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : AI850306
  • hSERPINA1

    hSERPINA1

    hSERPINA1

    • Nomenclature : C57BL/6JSmoc-Se
    • KI/KO Gene : Serpina1e
    • Strain : Repository Live
    • Target : Tumor Targets
    • Description : Model Descripti
  • hSIRPA(BALB/c,2)

    hSIRPA(BALB/c,2)

    hSIRPA(BALB/c,2)

    • Nomenclature : BALB/cAnSmoc-Si
    • KI/KO Gene : Sirpa
    • Research Application : Immunotherapy
    • Strain : Embryo cryopres
    • Target : Immune Checkpoi
  • hSIRPA(BALB/c)

    hSIRPA(BALB/c)

    hSIRPA(BALB/c)

    • Nomenclature : BALB/cAnSmoc-Si
    • KI/KO Gene : Sirpa
    • Research Application : Immunotherapy
    • Strain : Developing
    • Description : Model Descripti
  • hSOST(2)

    hSOST(2)

    hSOST(2)

    • Nomenclature : C57BL/6JSmoc-So
    • KI/KO Gene : Sost
    • Strain : Repository Live
    • Target : Other Targets
    • Description : Model Descripti
  • hTGFBR2(2)

    hTGFBR2(2)

    hTGFBR2(2)

    • Nomenclature : C57BL/6JSmoc-Tg
    • KI/KO Gene : Tgfbr2
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : DNIIR, RIIDN, T
  • hTGFB1

    hTGFB1

    hTGFB1

    • Nomenclature : C57BL/6JSmoc-Tg
    • KI/KO Gene : Tgfb1
    • Strain : Developing
    • Target : Cytokines
    • Description : Model Descripti
  • hTIGIT/hCCR8

    hTIGIT/hCCR8

    hTIGIT/hCCR8

    • Nomenclature : C57BL/6JSmoc-Ti
    • KI/KO Gene : CCR8
    • Strain : Embryo cryopres
    • Target : Immune Checkpoi
    • Description : Model Descripti
  • hTIGIT(3)/hTNFRSF1B

    hTIGIT(3)/hTNFRSF1B

    hTIGIT(3)/hTNFRSF1B

    • Nomenclature : C57BL/6JSmoc-Ti
    • KI/KO Gene : TIGIT
    • Research Application : Immunotherapy
    • Strain : Developing
    • Description : Model Descripti
  • hTLR9/hOX40

    hTLR9/hOX40

    hTLR9/hOX40

    • Nomenclature : C57BL/6JSmoc-Tl
    • KI/KO Gene : Tnfrsf4
    • Research Application : Immune-related
    • Strain : Embryo cryopres
    • Target : Immune Checkpoi
  • hTLR8

    hTLR8

    hTLR8

    • Nomenclature : C57BL/6JSmoc-Tl
    • KI/KO Gene : Tlr8
    • Research Application : Immunotherapy
    • Strain : Repository Live
    • Target : Immune Checkpoi
  • hTLR4

    hTLR4

    hTLR4

    • Nomenclature : C57BL/6JSmoc-Tl
    • KI/KO Gene : Tlr4
    • Research Application : Immunotherapy
    • Strain : Embryo cryopres
    • Target : Immune Checkpoi
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