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Humanized Knockins

Shanghai Model Organisms Center, Inc.

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

  • hVWF

    hVWF

    • Nomenclature : C57BL/6JSmoc-Vw
    • KI/KO Gene : Vwf
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : VWD, F8VWF, AI5
  • R26-LSL-hIL15-Flag-IRES-EGFP

    • Nomenclature : C57BL/6JSmoc-Gt
    • KI/KO Gene : Gt(ROSA)26Sor
    • Strain : Repository Live
    • Target : Cytokines
    • Description : Model Descripti
  • hIL3/hCSF2(M-NSG)

    hIL3/hCSF2(M-NSG)

    • Nomenclature : M-NSG-Il3tm(hIL
    • Strain : Repository Live
    • Description : Model Descripti
  • hIL5/hIL5RA(M-NSG)

    hIL5/hIL5RA(M-NSG)

    • Nomenclature : M-NSG-Il5tm(hIL
    • Strain : Repository Live
    • Description : Model Descripti
  • hLILRB1-hLILRB2-Tg

    hLILRB1-hLILRB2-Tg

    • Nomenclature : C57BL/6JSmoc-Tg
    • Strain : Developing
    • Target : Tumor Targets
    • Description : Model Descripti
  • hMLKL

    hMLKL

    • Nomenclature : C57BL/6JSmoc-Ml
    • KI/KO Gene : Mlkl
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : 9130019I15Rik
  • hMET

    hMET

    • Nomenclature : C57BL/6JSmoc-Me
    • KI/KO Gene : Met
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : HGF, HGFR, Par4
  • hCXCL10

    hCXCL10

    • Nomenclature : C57BL/6JSmoc-Cx
    • KI/KO Gene : Cxcl10
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : C7, IP10, CRG-2
  • hCTLA-4/hCD28(BALB/c)

    hCTLA-4/hCD28(BALB/c)

    • Nomenclature : BALB/cAnSmoc-Ct
    • KI/KO Gene : CD28
    • Research Application : Immunotherapy
    • Strain : Embryo cryopres
    • Description : Model Descripti
  • hF3

    hF3

    hF3

    • Nomenclature : C57BL/6JSmoc-F3
    • KI/KO Gene : F3
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : TF, Cf3, Cf-3,
  • hFCGR-Tg

    hFCGR-Tg

    • Nomenclature : C57BL/6JSmoc-Tg
    • KI/KO Gene : FCGR2A
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : CD32, FCG2, FcG
  • hGPNMB

    hGPNMB

    • Nomenclature : C57BL/6JSmoc-Gp
    • KI/KO Gene : Gpnmb
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : DC-HIL,Dchil,ip
  • hGFRAL(BALB/c)

    hGFRAL(BALB/c)

    • Nomenclature : BALB/cAnSmoc-Gf
    • KI/KO Gene : Gfral
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : Gral, AY457637
  • hGUCY2C

    hGUCY2C

    • Nomenclature : C57BL/6JSmoc-Gu
    • KI/KO Gene : Gucy2c
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : Gcc, GC-C, AI89
  • hICAM1

    hICAM1

    • Nomenclature : C57BL/6JSmoc-Ic
    • KI/KO Gene : Icam1
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : CD54, Ly-47, Ic
  • hIGF1

    hIGF1

    • Nomenclature : C57BL/6JSmoc-Ig
    • KI/KO Gene : Igf1
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : Igf-1, Igf-I, C
  • hIGF2

    hIGF2

    • Nomenclature : C57BL/6JSmoc-Ig
    • KI/KO Gene : Igf2
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : Mpr, M6pr, Peg2
  • hIL15RA(2)

    hIL15RA(2)

    • Nomenclature : C57BL/6JSmoc-Il
    • KI/KO Gene : Il15ra
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : IL-15RA, AA6901
  • hIL17RB

    hIL17RB

    • Nomenclature : C57BL/6JSmoc-Il
    • KI/KO Gene : Il17rb
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : Evi27, Il17br,
  • hIL3/hCSF2(BALB/c)

    hIL3/hCSF2(BALB/c)

    • Nomenclature : BALB/cAnSmoc-Il
    • KI/KO Gene : IL3
    • Strain : Embryo cryopres
    • Description : Model Descripti
    • Synonyms : BPA, PSF, HCG
  • hCD19(BALB/c)

    hCD19(BALB/c)

    • Nomenclature : BALB/cAnSmoc-Cd
    • KI/KO Gene : Cd19
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : AW495831
  • hCD28/hPD-1/hPD-L1

    hCD28/hPD-1/hPD-L1

    • Nomenclature : C57BL/6JSmoc-Cd
    • KI/KO Gene : CD28
    • Strain : Developing
    • Description : Model Descripti
  • hCD27/hPD-1(BALB/c)

    hCD27/hPD-1(BALB/c)

    • Nomenclature : BALB/cAnSmoc-Cd
    • KI/KO Gene : CD27
    • Strain : Developing
    • Description : Model Descripti
    • Synonyms : Cd27, S152, T
  • hCD79A/hCD79B

    hCD79A/hCD79B

    • Nomenclature : C57BL/6JSmoc-Cd
    • KI/KO Gene : CD79a
    • Research Application : Immunotherapy
    • Strain : Embryo cryopres
    • Description : Model Descripti
  • hCD79A

    hCD79A

    • Nomenclature : C57BL/6JSmoc-Cd
    • KI/KO Gene : Cd79a
    • Research Application : Immune-related
    • Strain : Embryo cryopres
    • Description : Model Descripti