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Human Neutrophil gelatinase-associated lipocalin（NGAL）

BHI13300002
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Active Measurement of the antigen-antibody complex in particle-enhanced turbidimetric immunoassay . The increased degree of the turbidity can be determined turbidimetrically at 546 nm. Protein concentration is determined >1mg/ml by commercial NGAL reagent, Imm
Alternative Names 25 kDa alpha-2-microglobulin-related subunit of MMP-9
Description Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron,leading to limit bacterial growth.
Expression System Yeast
Protein Nature Recombinant
Shape Liquid, dissolved in 0.01M PBS, pH 7.4, 50% glycerol
Tag his
Resarch Areas Renal Function & Injury
Immunogen Species Homo Sapiens (Human)
Uniprot P80188
Purity >90% by SDS-PAGE
Storage Aliquot and store at -20 ° C or -80 ° C. Avoid repeated freeze / thaw cycles
SKU Supplier No. Size Your price Quantity
BHI13300002 CSB-DP001A 1mg $605.56
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