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Anti-TGFA Antibody BHA11300522
Alternative: Protransforming growth factor alpha|Transforming growth factor alpha|TGF-alpha|EGF-like TGF|ETGF|TGF type 1|TGFA|TGF α
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 2p13.3
Immunogen: Synthetic peptide, corresponding to amino acids 111-160 of Human TGFα.
Description: Transforming growth factor α (TGFα) is an acid- and heat-stable 50 amino acid protein originally found in rodents and humans. TGFα is 33% homologous at the amino acid level to epidermal growth factor (EGF). TGFα binds to the EGF receptor, mediates tyrosine phosphorylation of the receptor and promotes anchorage-independent growth of normal rat fibroblasts in soft agar in the presence of transforming growth factor β. TGFα is secreted by a variety of transformed cells and tumors, embryonic cells and some normal adult cells. TGFα bioactivity has been found in the urine of cancer patients. It has been suggested that it may act as an autocrine growth factor for the induction or maintenance of malignancy.
TARGETWeight: 10, 17 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: TGF α (R139) polyclonal antibody detects endogenous levels of TGF α protein.
Description: Immunohistochemistry (IHC) analyzes of TGFα (R139) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.