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Anti-MMP14 Antibody BHA11300402
Alternative: Matrix metalloproteinase-14|MMP 14|MMP-X1|Membrane-type matrix metalloproteinase 1|MT-MMP 1|MTMMP1|Membrane-type-1 matrix metalloproteinase|MT1-MMP|MT1MMP|MMP14
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 14q11.2
Immunogen: Synthetic peptide, corresponding to amino acids 480-520 of Human MMP-14.
Description: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. Membrane-type matrix metalloproteinases, including MT-MMP-1 (also designated MMP-14), MT-MMP-2 (also designated MMP-15), MT-MMP-3 (also designated MMP-16) and MT-MMP-4 (also designated MMP-17) are type I membrane proteins that function to activate other MMPs. MT-MMP activation appears to be mediated by members of the proprotein convertase family, suggesting that a proprotein convertase/MT-MMP/MMP cascade may be involved in the regulation of ECM turnover.
TARGETWeight: 53, 65 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: MMP-14 (P509) polyclonal antibody detects endogenous levels of MMP-14 protein.
Description: Immunohistochemistry (IHC) analyzes of MMP-14 (P509) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.