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Anti-TRAF2 Antibody BHA11300110
Alternative: TNF receptor-associated factor 2|E3 ubiquitin-protein ligase TRAF2|Tumor necrosis factor type 2 receptor-associated protein 3|TRAF2|TRAP3
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 9q34.3
Immunogen: Synthetic peptide, corresponding to the N-terminus of Human TRAF2.
Description: Tumor necrosis factor (TNF)-activated cell signaling is mediated primarily through the TNF receptor 1 (TNF-R1) and, to a lesser extent, TNF-R2. Both TNF receptors are members of the expanding TNF receptor superfamily, which includes the FAS antigen and CD40. Potential insight into an understanding of TNF receptor-mediated signaling was provided by the identification of two related proteins, TRAF1 and TRAF2 (for TNF receptor-associated factors 1 and 2, respectively). Both function to form heterodimeric complexes and associate with the cytoplasmic domain of TNF-R2. A third member of this protein family, alternatively designated CD40 bp, CRAF1, LAP1 or TRAF3, has been identified and shown to associate with the cytoplasmic domain of CD40. The similarity between a specific region of TRAF3 with regions of TRAF1 and TRAF2 define a “TRAF-C” domain that is necessary and sufficient for CD40 binding and homodimerization.
TARGETWeight: 56 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 118% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.Specificity: TRAF2 (S11) polyclonal antibody detects endogenous levels of TRAF2 protein.
Description: Western blot (WB) analysis of TRAF2 (S11) polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264.7 whole cell lysateLane3:PC12 whole cell lysate
Description: Western blot (WB) analysis of TRAF2 (S11) pAb at 1:500 dilutionLane1:SGC7901 whole cell lysate(40ug)Lane2:MCF-7 whole cell lysate(40ug)Lane3:C6 whole cell lysate(40ug)Lane4:AML-12 whole cell lysate(40ug)
Description: Western blot (WB) analysis of TRAF2 (S11) pAb at 1:500 dilutionLane1:LO2 whole cell lysate(40ug)Lane2:HCT116 whole cell lysate(40ug)Lane3:NIH-3T3 whole cell lysate(40ug)Lane4:C6 whole cell lysate(40ug)