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Home / Primary Antibodies / Polyclonal Antibodies

ZNF238 antibody

SKU : BHA10809641

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Mfr.No.	FNab09671
Alternative Names	58kDarepressorprotein ; C2H2171 ; RP58 ; TAZ1 ; TAZ1 ; TranscriptionalrepressorRP58 ; ZBTB18 ; ZFP238 ; zincfingerprotein238 ; ZincfingerproteinC2H2171 ; ZNF238
Background	ZNF238 is a member of the BTB/POZ-ZF protein family, which involve in development and cancer formation, for example BCL-6, PLZF, and HIC-1. It's a transcriptional repressor involve in myogenesis and brain development. By directly repressing the expression of two skeletal myogenesis inhibitors, ID2 and ID3, ZNF238 plays a key role in myogenesis. It can control cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Besides, ZNF238 involves in the organization of nuclear chromosomes, for its specific binding to the consensus DNA sequence that contains the E box core, and recruiting chromatin remodeling multiportein complex. ZNF238 proteins has apparent molecular masses of 60 and 48 kD. Specific binding is found for a 60-kDa band which corresponds to the full length of RP58 protein. In addition, a 48-kDa band, thought to be the truncated form 2 is detected(PMID: 9756912).
Categories	Primary Antibodies
Cellular Localization	Nucleus
Clonality	polyclonal
Description	ZNF238 is a member of the BTB/POZ-ZF protein family, which involve in development and cancer formation, for example BCL-6, PLZF, and HIC-1. It's a transcriptional repressor involve in myogenesis and brain development. By directly repressing the expression of two skeletal myogenesis inhibitors, ID2 and ID3, ZNF238 plays a key role in myogenesis. It can control cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Besides, ZNF238 involves in the organization of nuclear chromosomes, for its specific binding to the consensus DNA sequence that contains the E box core, and recruiting chromatin remodeling multiportein complex. ZNF238 proteins has apparent molecular masses of 60 and 48 kD. Specific binding is found for a 60-kDa band which corresponds to the full length of RP58 protein. In addition, a 48-kDa band, thought to be the truncated form 2 is detected (PMID: 9756912).
Host	Rabbit
Immunogen	zinc finger protein 238
Isotype	IgG
Molecular Weight	48 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Nucleus
Synonyms	58 kDa repressor protein, C2H2 171, RP58, TAZ 1, TAZ1, Transcriptional repressor RP58, ZBTB18, ZFP238, zinc finger protein 238, Zinc finger protein C2H2 171, ZNF238

Antigen	ZNF238
Uniprot	Q99592
Research Area	Metabolism
Weight	58kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IP, IHC

Description

ELISA ; WB ; IP ; IHC

Dilution

WB	1:500-1:5000
IP	1:500-1:5000
IHC	1:20-1:200

Tested Application

WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809641	FNab09671	100ug	$260		Add to Cart

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