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Home / Biochemicals / Small Molecules

YM-01

SKU : BHB11900012

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StressMarq Biosciences Inc.

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Mfr.No.	SIH-121
Alternative Names	2-((Z)-((E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride; YM-1
Appearance	Orange red solid
Function	Hsp70 Inhibitor
Mode Of Action	Inhibitor
Molecular Formula	C20H20ClN3OS2
Research Area	Cancer ; Heat Shock
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	409086-68-6
Molecular Weight	417.97
Scientific Background	YM-01 is an allosteric Hsp70 inhibitor. It binds with in Hsp70's nucleotide binding domain, adjacent to ATP/ADP binding pocket. It inhibits J-stimulated ATP turnover rate. It blocks Hsc70-bag1 interaction both in vitro and in vivo and enhances binding of Hsp70 to misfolded proteins. It reduces tau levels in tau-overexpressed HeLa cells, endogenous tau in neuroblastoma cells, and endogenous tau in primary neuron from rTg4510 mice, with EC50's of low micromolar. It recovers long-term potentiation deficits in brain slices from rTg4510 mice. It also has anti-cancer activity, with an EC50 value of low micromolar against several cancer cell lines. It destabilizes oncoproteins in cells, including Akt and Raf-1. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
Solubility	Soluble in warm water (2 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	>98% (HPLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Wang et al., 2013 Nature Chem. Biol. 9: 112-118. 2. Abisambra et al., 2013 Biol. Psychiatry, 74: 367-374. 3. Koren et al. PLoS One 7:e35566. 4. Morishima et al. 2011 Biochemistry. 50: 7146. 5. Davis et al. 2012 J. Immunol. 189: 4488.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900012-1	SIH-121-10MG	10 mg	$185		Add to Cart
BHB11900012-2	SIH-121-25MG	25 mg	$371		Add to Cart

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