Probable substrate-recognition component of a SCF-like ECS(Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.
Categories
Primary Antibodies
Cellular Localization
Cytosol, Ntracellular
Clonality
polyclonal
Description
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.
Host
Rabbit
Immunogen
WD repeat and SOCS box-containing 1
Isotype
IgG
Molecular Weight
56 kDa
Reactivity
Human
Regulatory
RUO
Subcellular Location
cytosol,intracellular
Synonyms
SWIP1, WSB 1, WSB1
Uniprot
Q9Y6I7
Gene Id
26118
Research Area
Developmental biology, Signal Transduction, Metabolism
Weight
47kDa,Observed 31kDa,56kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)