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Home / Proteins & Peptide

VEGF165, Human

SKU : BHP18500023

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iXCells Biotechnologies

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Mfr.No.	IX02689, IX02689-1, IX02689-10, IX02689-100, IX02689-50
Reconstitution	Reconstituted in ddH2O at 100 ug/ml.
Description	Vascular Endothelial Growth Factor (VEGF) is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, Vascular Endothelial Growth Factor (VEGF) plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates Vascular Endothelial Growth Factor (VEGF) in the induction of tumor metastasis and intra-ocular neovascular syndromes. Vascular Endothelial Growth Factor (VEGF) signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product.Recombinant human Vascular Endothelial Growth Factor A165 (rhVEGF-A165) produced in Pichia pastoris is a disulfide-linked homodimer containing two polypeptide chains of 165 amino acids each. A fully biologically active molecule, rhVEGF-A165 has a molecular mass of 38.2kDa analyzed by non-reducing SDS-PAGE and is obtained by chromatographic techniques.
Formulation	Lyophilized after extensive dialysis against 25 mM HEPES and 150 mM NaCl, pH 7.0.
Molecular Weight	38.2kDa, observed by non-reducing SDS-PAGE
Source	P. pastoris
Host	Human
Endotoxin Level	0.5 EU/ug, determined by LAL method.
Bioactivity	ED50 of 1-5ng/ml, measured by the dose-dependent stimulation of the proliferation of HUVEC cells, corresponding to a specific activity of 2x 105-1x 106 units/mg.

Synonyms	VPF, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen
Sequence	APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYPDEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQIMRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPCSERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRCDKPRR

Purity	95% as analyzed by reducing SDS-PAGE.
Storage	Lyophilized recombinant human Vascular Endothelial Growth Factor A165 (rhVEGF-A165) remains stable up to 12 months at lower than -70°C from date of receipt. Upon reconstitution, rhVEGF-A165 should be stable up to 4 week at 4°C or up to 6 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500023-1	IX02689-1	1mg	$1872		Add to Cart
BHP18500023-2	IX02689-10	10ug	$107		Add to Cart
BHP18500023-3	IX02689-100	100ug	$494		Add to Cart
BHP18500023-4	IX02689-50	50ug	$344		Add to Cart

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