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Home / VECTOR &VIRUS / Lentivirus

PPARdelta Reporter Lentivirus

SKU : BHV19400073

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Mfr.No.	LTV-0079, LTV-0079-1S, LTV-0079-2S, LTV-0079-3S, LTV-0079-4S, LTV-0079-5S, LTV-0079-6S
Description	PPARdelta Reporter Lentivirus: High-quality, lentiviral transcription factor (TF) reporter system that provides a sensitive fluorescent or luminescent readout for human/mouse PPARdelta transcriptional activity in mammalian cells. The PPARdelta Reporter Lentivirus is constructed with tandem repeats of the consensus PPARdelta DNA-binding elements which is transcriptionally responsive to the transcription factor PPARdelta. Peroxisome proliferator activated receptor (PPAR)beta/delta, also called nuclear hormone receptor 1 (NUC1), is a nuclear receptor that in humans is encoded by the PPARD gene. Like other PPARs, PPARD heterodimerizes with the retinoid X receptor (RXR) to activate or repress expression of downstream target genes by binding to PPAR response elements (PPREs) in their promoters. In the absence of ligand binding, PPARD-RXR complexes are associated with co-repressive factors and become active upon binding to an activating ligand such as linolenic acid. PPARD is especially important in regulating fatty acid uptake, transport, and beta-oxidation as well as insulin secretion and sensitivity. Cancer cells upregulate PPRAD expression/activity as a defense mechanism against nutritional deprivation and energy stresses, improving their survival and promoting cancer progression. The reporter lentivirus is purified by PEG precipitation and sucrose gradient centrifugation, and is ideal for studying PPARdelta transcriptional activity in difficult-to-transfect cells including primary and/or thawed cells.
Promoter	EF1a
Serotype	VSV-G
Reporter	Firefly Luc, RFP, GFP
Response Element	PPARdelta response element
Selection	Blasticidin, Puromycin
Signaling pathway	PPARdelta Signaling Pathway
Species	Human/mouse
Applications Range	Monitor transcriptional activity of PPARdelta in mammalian cells, screen for activators or inhibitors of PPARdelta transcriptional activity. The fluorescent reporter enables convenient readout using flow cytometry, fluorescence microscopy, etc.
Virus Type	TF Reporter Lentivirus

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Combination SKU	Supplier No.	Amount (TU)	Selection	Reporter	Promoter	Your price	Quantity
BHV19400073-1	LTV-0079-1S	5x10^6	Puromycin	GFP	EF1a	$595		Add to Cart
BHV19400073-2	LTV-0079-2S	5x10^6	Blasticidin	RFP	EF1a	$595		Add to Cart
BHV19400073-3	LTV-0079-3S	2x10^6	Puromycin	Firefly Luc	EF1a	$595		Add to Cart
BHV19400073-4	LTV-0079-4S	2x10^6	Blasticidin	Firefly Luc	EF1a	$595		Add to Cart
BHV19400073-5	LTV-0079-5S	5x10^6	Blasticidin	GFP	EF1a	$595		Add to Cart
BHV19400073-6	LTV-0079-6S	5x10^6	Puromycin	RFP	EF1a	$595		Add to Cart

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