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Home / VECTOR &VIRUS / Lentivirus

BRE Reporter Lentivirus

SKU : BHV19400070

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Mfr.No.	LTV-0075, LTV-0075-1S, LTV-0075-2S, LTV-0075-3S, LTV-0075-4S, LTV-0075-5S, LTV-0075-6S
Description	BRE Reporter Lentivirus: High-quality, lentiviral transcription factor (TF) reporter system that provides a sensitive fluorescent or luminescent readout for human/mouse bone morphogenic protein (BMP) signaling pathway in mammalian cells. The lentiviral construct contains inverted repeats of mouse Id2 promoter BMP response elements (BRE) plus Smad4 DNA-binding motif. Upon BMP signaling pathway activation, Smad1/5/8 are activated and form a complex with Smad4 that binds the BRE, directing transcription of the reporter gene. The BMP signaling pathway is associated with embryogenesis, organ development, and adult tissue homeostasis. The reporter lentivirus is purified by PEG precipitation and sucrose gradient centrifugation, and is ideal for studying BMP signaling pathways in difficult-to-transfect cells including primary and/or thawed cells.
Promoter	EF1a
Serotype	VSV-G
Reporter	Firefly Luc, RFP, GFP
Response Element	BMP response elements (BRE)
Selection	Blasticidin, Puromycin
Signaling pathway	Bone morphogenic protein (BMP) Signaling Pathway
Species	Human/mouse
Applications Range	Monitor transcriptional activity of bone morphogenic protein (BMP) signaling pathway in mammalian cells, screen for activators or inhibitors of BMP signaling pathway. The fluorescent reporter enables convenient readout using flow cytometry, fluorescence microscopy, etc. The BMP response element (BRE) reporter lentivirus is constructed with inverted repeats of mouse Id2 promoter BRE plus Smad4 DNA-binding motif to respond to BMP proteins. BMP signaling pathway is associated with embryogenesis, organ development, and adult tissue homeostasis. Smad1/5/8 are activated by BMP signal transduction, which form a complex with Smad4 that binds BRE sites in the promoters of target genes to regulate gene expression.
Virus Type	TF Reporter Lentivirus

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Combination SKU	Supplier No.	Amount (TU)	Selection	Reporter	Promoter	Your price	Quantity
BHV19400070-1	LTV-0075-1S	5x10^6	Puromycin	GFP	EF1a	$595		Add to Cart
BHV19400070-2	LTV-0075-2S	5x10^6	Blasticidin	RFP	EF1a	$595		Add to Cart
BHV19400070-3	LTV-0075-3S	2x10^6	Puromycin	Firefly Luc	EF1a	$595		Add to Cart
BHV19400070-4	LTV-0075-4S	2x10^6	Blasticidin	Firefly Luc	EF1a	$595		Add to Cart
BHV19400070-5	LTV-0075-5S	5x10^6	Blasticidin	GFP	EF1a	$595		Add to Cart
BHV19400070-6	LTV-0075-6S	5x10^6	Puromycin	RFP	EF1a	$595		Add to Cart

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