Model Description: These mice carry loxP sites flanking exon 3-5 of Tsc2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tsc2 gene.
Official Symbol: Tsc2
NCBI ID: 22084
MGI ID: 102548
Ensembl ID: ENSMUSG00000002496
Pubmed: Tsc2
Human Ortholog: TSC2
Nomenclature
C57BL/6JSmoc-Tsc2tm1(flox)Smoc
Exon
Exon 3-5
Disease
Uterine Fibroid
Disease
Spontaneous Tumor
KI/KO Gene
Tsc2
Notes
Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pgr-Cre mice.
Prizant H, Sen A, Light A, Cho SN, DeMayo FJ, Lydon JP, Hammes SR, Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs. Mol Endocrinol. 2013 Sep;27(9):1403-14