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Home / Antibodies

TRAIL R2 Antibody (DR5) (R30940)

SKU : BHA17104476

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NSJ Bioreagents

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Mfr.No.	R30940
Clonality	Polyclonal
Description	TNFRSF10B (Tumor necrosis factor receptor superfamily, member 10b) has many names, including DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL R2, KILLER/DR5. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. By analysis of radiation hybrid panels, Walczak et al.(1997) mapped the gene to chromosome 8p22-p21. Northern blot analysis indicated that TRAIL R2 was expressed as a 4.4-kb mRNA in all tissues tested, with the highest levels of expression in peripheral blood lymphocytes, spleen, and ovary.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the C-terminus of human DR5/TRAIL R2 (DPTETLRQCFDDFADL) was used as the immunogen for this TRAIL R2 antibody.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	O14763

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the TRAIL R2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB, IHC-P
Dilution	Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104476	R30940	100 ug	$419		Add to Cart

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