Slc6a11-CreERT2

Mfr.No.	NM-KI-200130
Description	Model Description: A CreERT2-polyA expression cassette was knocked into the Slc6a11 gene start codon site. Slc6a11 encodes GAT3 (Gabt4), a sodium-dependent transporter that uptakes the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which ends the GABA neurotransmission. When Slc6a11-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLC6A11positive cells. Defects in Slc6a11 may result in epilepsy or behavioral and intellectual defects. Official Symbol: Slc6a11 NCBI ID link: 243616 MGI ID link: 95630 Ensembl ID link: ENSMUSG00000030307 Pubmed link: Slc6a11 Human Ortholog: SLC6A11
Nomenclature	C57BL/6JSmoc-Slc6a11^{em1(CreERT2-polyA(SV40)Smoc}
Strain	Embryo cryopreservation
KI/KO Gene	Slc6a11
Synonyms	GAT4, Gat3, Gabt4, D930045G19Rik, E130202I16Rik

Applications Range	Cre recombinase tool; Neuroscience
Research Application	Cre/Dre-Driver

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