Nos1-IRES-Cre

Mfr.No.	NM-KI-200113
Description	Model Description: A IRES-iCre expression cassette was knocked into the Nos1 gene stop codon site. Official Symbol: Nos1 NCBI ID link: 18125 MGI ID link: 97360 Ensembl ID link: ENSMUSG00000029361 Pubmed link: Nos1 Human Ortholog: NOS1
Nomenclature	C57BL/6JSmoc-Nos1^{em1(IRES-iCre)Smoc}
Strain	Sperm cryopreservation
KI/KO Gene	Nos1
Synonyms	NO, NOS, bNOS, nNOS, N-NOS, NOS-I, Nos-1, NC-NOS, 2310005C01Rik

Applications Range	Cre recombinase tool; NOS1, the neurogenic nitric oxide synthase, is a key enzyme responsible for the production of the signaling molecule nitric oxide (NO) by neurons. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying diseases with impaired or reduced nitric oxide release, such as achalasia of cardia, hirschsprung's disease, hypertrophic pyloric stenosis, etc.
Research Application	Cre/Dre-Driver

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