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Home / Primary Antibodies / Polyclonal Antibodies

TNF-R1 Antibody - SPC-170

BHA11906982
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Contact us to order
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+1 866.986.9598
Email
[email protected]
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Swissprot P19438
Accession Number P19438
Gene Id 8666
Target TNFR1
Research Area Cancer, Apoptosis, Cell Signaling, Cardiovascular System, Atherosclerosis
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Scientific Background The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences(1,3).TNFR1 also known as p55/p60 is a high affinity receptor for TNF-alpha. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases (1, 2). The TNF-alpha/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis.
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~55kDa. Other bands present may be the result of oligomerization, self-aggregation and/or cleavage of the TNF-R1 extracellular domain.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, IP, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; IP
Dilution WB (1:1000), IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Kontermann R.E., et al. (2008) J Immunother. 31(3):225-34.

2. Hehlgans T. and Pfeffer K. (2005) Immunology. 115(1):1-20.

3. Al-Lamki S., et al. (2005) The Faseb Journal. 19:1638-1645.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11906982-1 SPC-170D Unconjugated 100 ug $311
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BHA11906982-2 SPC-170D-A390 ATTO 390 100 ug $365
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BHA11906982-3 SPC-170D-A488 ATTO 488 100 ug $363
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BHA11906982-4 SPC-170D-A594 ATTO 594 100 ug $363
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BHA11906982-5 SPC-170D-ALP Alkaline Phosphatase 100 ug $356
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BHA11906982-6 SPC-170D-APC APC 100 ug $362
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BHA11906982-7 SPC-170D-BI Biotin 100 ug $359
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BHA11906982-8 SPC-170D-FITC FITC 100 ug $354
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BHA11906982-9 SPC-170D-HRP HRP 100 ug $350
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BHA11906982-10 SPC-170D-PCP PerCP 100 ug $362
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BHA11906982-11 SPC-170D-RPE RPE 100 ug $360
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BHA11906982-12 SPC-170S Unconjugated 12 ug $44
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