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Home / Antibodies

TNF alpha Antibody (V7163SAF)

SKU : BHA17126083

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NSJ Bioreagents

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Mfr.No.	V7163SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	Tumor Necrosis Factor Alpha (TNF alpha) is a cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. (UniProt)
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Full length human recombinant protein was used as the immunogen for the TNF alpha antibody.
Isotype	Mouse IgM, kappa
Species Reactivity	Human, Rat
Note	Titering of the TNF alpha antibody may be required for optimal performance.

Uniprot	P01375

Format	Purified
Purity	PEG precipitation
Storage	Store the TNF alpha antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IF, IHC-P, FACS
Description	Immunofluorescence: 1-2ug/ml,Flow cytometry: 1-2ug/million cells,Immunohistochemistry (FFPE): 2-4ug/ml for 30 min at RT

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17126083	V7163SAF-100UG	100 ug	$499		Add to Cart

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