Studies have found that spermatogonial cell quality changes during puberty development

Copyright © iCell Bioscience Inc, Shanghai 2018-2019

In order to collect published data on the number of spermatogonia in healthy children's testes and to calculate the reference value of sperm count throughout adolescence, the researchers systematically conducted a literature survey on PubMed and EMBASE, with a primary focus on each transverse tubular section throughout puberty. Sperm cell number (S/T) and spermatogonial density (S/V) per cubic centimeter of testis. The primary test parameters were polynomial multiple regression analysis of S/T and S/V for healthy boys aged 0-14.

The researchers found raw quantitative data for S/T and S/V in healthy boys (n = 334 and 62). Through polynomial multiple regression analysis of S/T and S/V, the researchers found that the number of spermatogonia showed a clear pattern throughout puberty: the first three years of decline, followed by a slow rise of 6-7 years, arriving at 11 years old Balanced, there will be a sharp tilt between the ages of 13 and 14 to reach the value of puberty. The link between S/T and S/V allows researchers to extrapolate S/T and S/V to create a reference value for S/V throughout puberty.

The researchers found that spermatogonia quality changes during different stages of puberty. The value of this study may be used as a benchmark for the clinical study of the effects of disease and gonadal toxin treatment on the number of prepubertal sperm. Reference values for the number of spermatogonia will also help assess the quality of testicular biopsy in boys undergoing pre-puberty protection.