SR 12460

Mfr.No.	T37449
Description	SR 12460 is a mimetic of the IkappaB kinase beta (IKKbeta) NEMO/IKKgamma-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-kappaB essential modulator (NEMO/IKKgamma) and IKKbeta.1It inhibits TNF-alpha-induced NF-kappaB activation in a reporter assay when used at concentrations ranging from 25 to 150 uM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in themdxmouse model of Duchenne muscular dystrophy.
Molecular Formula	C15H14ClF2N3O
Signaling Pathways	Others
Smiles	N(C(CNCCC1=CC(F)=CC(F)=C1)=O)C2=CC=C(Cl)C=N2
Cas Number	2055101-66-9
Molecular Weight	325.74
Target	Others

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SKU	Supplier No.	Size	Your price
BHB20426594	T37449	1 mg	$95	Add to Cart
BHB20426594	T37449	5 mg	$278	Add to Cart
BHB20426594	T37449	10 mg	$492	Add to Cart
BHB20426594	T37449	25 mg	$1140	Add to Cart