SNCA (Synuclein Alpha) 
Gene and Protein Information   (UniProtKB/Swiss-Prot）
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion, and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca (2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein Receptors) at the presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). SYUA_HUMAN,P37840
 
Alternate names for SNCA Gene

• Synuclein Alpha ^{HOGO NCBI ensembl}
• Alpha-Synuclein ^{HOGO NCBI UniProtKB/Swiss-Prot}
• Synuclein, Alpha (Non A4  Component Of Amyloid Precursor) ^HOGO NCBI
• PARK1 ^{NCBI UniProtKB/Swiss-Prot}
• NACP ^{NCBI UniProtKB/Swiss-Prot}
• Parkinson Disease (Autosomal Dominant, Lewy Body) 4 ^HOGO
• Non-A4 Component Of Amyloid Precursor ^{UniProtKB/Swiss-Prot}
• Non A4 Component Of Amyloid Precursor ^HOGO

• Non A-Beta Component Of AD Amyloid ^NCBI
• Non-A Beta Component Of AD Amyloid ^{UniProtKB/Swiss-Prot}
• Truncated Alpha Synuclein ^NCBI
• Synuclein Alpha-140 ^NCBI
• I+/--Synuclein ^NCBI
• Α-Synuclein ^HOGO
• PARK4 ^NCBI
• PD1 ^NCBI

 
Additional gene information for SNCA Gene

HGNC(11138)   Entrez Gene(6622)  Ensembl(ENSG0000014ensembl335)  OMIM(163890)  UniProtKB(P37840)
Monarch Initiative  DataMed  HumanCyc