WP-1130

Mfr.No.	SIH-337
Alternative Names	(2E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide
Appearance	Pale Yellow Solid
Function	DUB inhibitor
Inchi	InChI=1S/C19H18BrN3O/c1-2-7-17(14-8-4-3-5-9-14)23-19(24)15(13-21)12-16-10-6-11-18(20)22-16/h3-6,8-12,17H,2,7H2,1H3,(H,23,24)/b15-12+/t17-/m0/s1
Inchikey	LIDOPKHSVQTSJY-VMEIHUARSA-N
Mode Of Action	Inhibitor
Molecular Formula	C19H18BrN3O
Pubchem Cid	11222830
Research Area	Cancer ; Apoptosis
Safety Phrases	Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Smiles	CCC[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	856243-80-6
Molecular Weight	384.3
Scientific Background	A novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Blocks Jak2 signaling via Jak2 ubiquitination.
Solubility	Soluble in 45 mg/ml DMSO, 25 mg/ml Ethanol
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. KapuriaV., et al. (2010) Cancer Res. 70: 9265. 2. Kapuria V., et al. (2011) Cell Signal. 23: 2076.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900125-1	SIH-337-5MG	5 mg	$145		Add to Cart
BHB11900125-2	SIH-337-25MG	25 mg	$457		Add to Cart