Wortmannin

Mfr.No.	SIH-392
Alternative Names	SL-2052, KY12420 ;
Appearance	White to off-white solid.
Function	Autophagy inhibitor
Inchi	InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
Inchikey	QDLHCMPXEPAAMD-QAIWCSMKSA-N
Mode Of Action	Inhibitor
Molecular Formula	C23H24O8
Pubchem Cid	312145
Sd File	C23H24O8 APtclcactv04251417312D 0 0.00000 0.00000 55 59 0 0 1 0 0 0 0 0999 V2000 5.5021 -0.8800 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 6.3842 1.6615 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 5.4862 2.1893 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 4.5921 0.6268 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 4.5921 -1.3868 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 7.3722 -2.5286 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7319 -0.8769 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6361 -0.3800 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6240 2.6959 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 0.0968 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8486 -2.3668 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1002 0.6200 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.0498 3.9493 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.4900 -3.9493 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8486 1.6068 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.5841 1.6684 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1572 2.3504 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.7426 3.2992 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8602 0.6068 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7319 0.1169 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.8602 -1.3668 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.2342 0.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7119 3.1998 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4862 -2.9493 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2342 -0.8800 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3842 -2.4215 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5841 -2.4284 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.5021 0.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3681 0.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.8521 -1.6584 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.3681 -1.3800 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1571 1.3078 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0522 0.9317 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0522 -1.6917 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3705 2.2505 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9741 1.5576 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.5188 1.8468 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6961 2.6571 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9461 0.1569 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0992 -0.0700 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3261 -0.9169 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.3336 3.4864 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6185 3.9067 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.6582 -3.0787 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9382 3.2305 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0895 3.0101 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3099 2.1614 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1359 -0.4066 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3389 -0.3973 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6838 0.6302 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4667 -0.2194 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3162 -0.4365 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2287 -2.3596 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8415 -2.9867 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4686 -2.3739 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 25 30 1 0 0 0 0 6 30 1 0 0 0 0 5 27 1 0 0 0 0 24 27 1 0 0 0 0 4 20 1 6 0 0 0 19 20 1 0 0 0 0 12 22 2 0 0 0 0 13 23 2 0 0 0 0 14 24 2 0 0 0 0 7 21 1 0 0 0 0 11 21 1 0 0 0 0 15 19 2 0 0 0 0 1 28 1 0 0 0 0 1 31 1 0 0 0 0 1 5 1 0 0 0 0 1 8 1 1 0 0 0 2 29 1 0 0 0 0 2 3 1 0 0 0 0 2 17 1 0 0 0 0 2 32 1 6 0 0 0 28 29 2 0 0 0 0 4 28 1 0 0 0 0 22 29 1 0 0 0 0 3 16 1 0 0 0 0 3 23 1 0 0 0 0 3 9 1 1 0 0 0 25 31 2 0 0 0 0 26 31 1 0 0 0 0 22 25 1 0 0 0 0 4 16 1 0 0 0 0 5 7 1 6 0 0 0 24 26 1 0 0 0 0 6 26 2 0 0 0 0 18 23 1 0 0 0 0 17 18 1 0 0 0 0 10 19 1 0 0 0 0 4 33 1 0 0 0 0 5 34 1 0 0 0 0 16 35 1 0 0 0 0 16 36 1 0 0 0 0 17 37 1 0 0 0 0 17 38 1 0 0 0 0 8 39 1 0 0 0 0 8 40 1 0 0 0 0 8 41 1 0 0 0 0 18 42 1 0 0 0 0 18 43 1 0 0 0 0 6 44 1 0 0 0 0 9 45 1 0 0 0 0 9 46 1 0 0 0 0 9 47 1 0 0 0 0 7 48 1 0 0 0 0 7 49 1 0 0 0 0 10 50 1 0 0 0 0 10 51 1 0 0 0 0 10 52 1 0 0 0 0 11 53 1 0 0 0 0 11 54 1 0 0 0 0 11 55 1 0 0 0 0 M END $$$$
Research Area	Cancer ; Autophagy
Safety Phrases	Classification: D1A- Very Toxic Material Causing Immediate and Serious Toxic Effects, Highly toxic by ingestion, Highly toxic by skin absorption Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H300 + H310- Fatal if swallowed or in contact with skin H330- Fatal if inhaled. Precautionary statements: P260- Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264- Wash hands thoroughly after handling. P280- Wear protective gloves/ protective clothing. P284- Wear respiratory protection. P302 + P350- IF ON SKIN: Gently wash with plenty of soap and water. P310- Immediately call a POISON CENTER or doctor/ physician.
Smiles	[C@@]15(C4=C(C(C2=C1[C@@H](C[C@]3([C@H]2CCC3=O)C)OC(=O)C)=O)OC=C4C(O[C@@H]5COC)=O)C
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	19545-26-7
Molecular Weight	428.44
Scientific Background	Wortmannin is a steroid metabolite from the fungi Penicillium funiculosum. It specifically and irreversibly inhibits phosphatidylinositol 3-kinase (PI3-K). This in turn has been shown to inhibit the metabolic effects of insulin, yet the insulin receptor kinase activity is not altered. Because PI3-K is involved in membrane trafficking, and membrane trafficking is important in autophagy, Wortmannin also inhibits autophagy.
Solubility	Soluble in DMSO (50 mg/ml), methanol (5 mg/ml) or 100% ethanol (25 mg/ml).
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.001
Purity	≥98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Powis G., et al. (1994). Cancer Res. 54(9): 2419-23. 2. Hazeki O., et al. (1996). J Lipid Mediat Cell Signal. 14(1-3): 259-61. 3. Lee A., et al. (1995). FEBS Lett. 361(1): 51-4. 4. Blommaart E. F., et al. (1997). Eur J Biochem. 243(1-2): 240-6.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900180-1	SIH-392-1MG	1 mg	$62		Add to Cart
BHB11900180-2	SIH-392-5MG	5 mg	$241		Add to Cart

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