Terazosin Hydrochloride

Mfr.No.	SIH-516
Alternative Names	1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine
Appearance	White to off-white solid
Function	Alpha adrenergic antagonist, and Hsp90 Activator
Inchi	InChI=1S/C19H25N5O4.ClH.H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;/h10-11,1
Inchikey	MWYNOTLRCUQCKD-UHFFFAOYSA-M
Mode Of Action	Antagonist
Molecular Formula	C19H25N5O4·HCl
Pubchem Cid	44383
Sd File	C19H27ClN5O5 APtclcactv08071519252D 0 0.00000 0.00000 57 58 0 0 0 0 0 0 0 0999 V2000 9.0404 1.2753 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9465 1.7892 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8105 1.2859 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 11.6785 1.7825 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.9465 2.8308 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0404 3.3447 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1464 2.8100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1464 1.8100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2804 1.3100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.4144 1.8100 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.4144 2.8100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2804 3.3100 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5484 3.3100 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.5484 4.3100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6823 4.8100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8163 4.3100 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.9503 4.8100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9503 5.8100 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.0843 4.3100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.9797 3.3155 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1.0016 3.1076 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.5016 3.9736 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1707 4.7167 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8163 3.3100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6823 2.8100 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2804 0.3100 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 10.8105 3.3341 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 10.8067 4.3341 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8566 7.8234 0.0000 Cl 0 5 0 0 0 0 0 0 0 0 0 0 6.1083 10.3402 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.0332 0.6554 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9864 1.2444 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.2166 2.0904 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.3706 2.3206 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0332 3.9646 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1589 4.2023 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7604 4.8926 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0809 5.2849 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2838 5.2849 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6042 3.9723 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4352 2.8554 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.1932 2.5179 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0867 4.4343 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 3.6092 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4807 5.2537 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.6691 5.0812 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2057 3.4177 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6043 2.7274 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2838 2.3351 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0809 2.3351 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7435 0.0000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8174 0.0000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4267 4.3365 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8043 4.9541 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1867 4.3318 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6452 10.6502 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.5714 10.6502 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 2 0 0 0 0 2 3 1 0 0 0 0 3 4 1 0 0 0 0 2 5 1 0 0 0 0 5 6 2 0 0 0 0 6 7 1 0 0 0 0 7 8 2 0 0 0 0 1 8 1 0 0 0 0 8 9 1 0 0 0 0 9 10 2 0 0 0 0 10 11 1 0 0 0 0 11 12 2 0 0 0 0 7 12 1 0 0 0 0 11 13 1 0 0 0 0 13 14 1 0 0 0 0 14 15 1 0 0 0 0 15 16 1 0 0 0 0 16 17 1 0 0 0 0 17 18 2 0 0 0 0 17 19 1 0 0 0 0 19 20 1 0 0 0 0 20 21 1 0 0 0 0 21 22 1 0 0 0 0 22 23 1 0 0 0 0 19 23 1 0 0 0 0 16 24 1 0 0 0 0 24 25 1 0 0 0 0 13 25 1 0 0 0 0 9 26 1 0 0 0 0 5 27 1 0 0 0 0 27 28 1 0 0 0 0 1 31 1 0 0 0 0 4 32 1 0 0 0 0 4 33 1 0 0 0 0 4 34 1 0 0 0 0 6 35 1 0 0 0 0 14 36 1 0 0 0 0 14 37 1 0 0 0 0 15 38 1 0 0 0 0 15 39 1 0 0 0 0 19 40 1 0 0 0 0 21 41 1 0 0 0 0 21 42 1 0 0 0 0 22 43 1 0 0 0 0 22 44 1 0 0 0 0 23 45 1 0 0 0 0 23 46 1 0 0 0 0 24 47 1 0 0 0 0 24 48 1 0 0 0 0 25 49 1 0 0 0 0 25 50 1 0 0 0 0 26 51 1 0 0 0 0 26 52 1 0 0 0 0 28 53 1 0 0 0 0 28 54 1 0 0 0 0 28 55 1 0 0 0 0 30 56 1 0 0 0 0 30 57 1 0 0 0 0 M CHG 1 29 -1
Research Area	Cancer ; Apoptosis ; Neuroscience ; Neurotransmitter Receptors ; Alpha-2 Adrenergic Receptors
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard Statements: H302 - Harmful if swallowed.
Smiles	C1=C(OC)C(=CC2=C1C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC.[Cl-].O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	63074-08-8
Molecular Weight	423.89
Scientific Background	Terazosin (TZ) which is marketed as an alpha1-adrenergic receptor antagonist, has been shown to alleviate organ damaged and increase survival in rodent models of sepsis and stroke in vivo (1). It inhibits apoptosis in macrophages by activation of Pgk1 and Hsp90 (1).
Solubility	Soluble to 20mg/ml in warm water
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.1
Purity	>98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Chen X., et al. (2015) Nature Chem Biol. 11:19-25. 2. Hancock A.A., et al. (1995) J Recept Signal Transduct Res. 15: 863. 3. Kyncl J.J. (1986) Am J Med. 80:12.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900299-1	SIH-516-20MG	20 mg	$62		Add to Cart
BHB11900299-2	SIH-516-100MG	100 mg	$185		Add to Cart

Terazosin Hydrochloride

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