GSK-3beta inhibitor 9 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3beta inhibitor with the IC 50 of 35 nM. GSK-3beta inhibitor 9 exhibits good pharmacokinetic profiles including favorable BBB penetration. GSK-3beta inhibitor 9 is able to be used for the research of Alzheimer s disease (1).