SB216763

Mfr.No.	SIH-510
Alternative Names	SB 216763, 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Appearance	Orange solid
Function	GSK-3 kinase inhibitor
Inchi	InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
Inchikey	JCSGFHVFHSKIJH-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C19H12Cl2N2O2
Pubchem Cid	176158
Sd File	C19H12Cl2N2O2 APtclcactv07301413332D 0 0.00000 0.00000 37 40 0 0 0 0 0 0 0 0999 V2000 6.8593 -1.2848 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4635 -2.2848 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5974 -1.7848 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5974 -0.7848 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4635 -0.2848 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4985 0.4170 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4985 0.4188 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5015 2.1508 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5864 -3.0401 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0419 2.1414 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2757 -0.4801 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0000 1.2822 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0000 1.2857 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5015 2.1491 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2818 3.0401 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.3460 0.1886 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5864 0.4704 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.0000 1.2805 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.5892 2.0885 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5380 0.7778 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0030 3.0143 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 1.2874 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.5397 1.7778 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.3295 -0.7848 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.3295 -1.7848 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.2757 -2.0895 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.9971 -3.2327 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7790 -3.6294 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1757 -2.8475 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4793 -1.2848 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4635 -2.9048 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0605 -2.0948 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0605 -0.4748 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4635 0.3352 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8076 -0.1204 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1876 -0.1176 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.1924 2.6883 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9 26 1 0 0 0 0 9 27 1 0 0 0 0 9 28 1 0 0 0 0 9 29 1 0 0 0 0 1 26 1 0 0 0 0 25 26 1 0 0 0 0 1 11 2 0 0 0 0 1 30 1 0 0 0 0 11 24 1 0 0 0 0 11 17 1 0 0 0 0 24 25 1 0 0 0 0 5 24 2 0 0 0 0 2 25 2 0 0 0 0 2 3 1 0 0 0 0 2 31 1 0 0 0 0 3 4 2 0 0 0 0 3 32 1 0 0 0 0 4 5 1 0 0 0 0 4 33 1 0 0 0 0 5 34 1 0 0 0 0 17 18 2 0 0 0 0 17 20 1 0 0 0 0 18 19 1 0 0 0 0 12 18 1 0 0 0 0 15 19 2 0 0 0 0 19 23 1 0 0 0 0 20 23 1 0 0 0 0 10 23 1 0 0 0 0 16 20 2 0 0 0 0 6 12 1 0 0 0 0 12 14 2 0 0 0 0 6 7 2 0 0 0 0 6 35 1 0 0 0 0 7 13 1 0 0 0 0 7 36 1 0 0 0 0 8 13 2 0 0 0 0 13 22 1 0 0 0 0 8 14 1 0 0 0 0 8 37 1 0 0 0 0 14 21 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.
Smiles	CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	280744-09-4
Molecular Weight	371.2
Scientific Background	SB216763 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor. It inhibits both human GSK-3α and GSK-3β. SB216763 has been shown to stimulate glycogen synthesis in human liver cells and mimic other actions of insulin. SB216763 is cell-permeable and ATP-competitive.
Solubility	Soluble in DMSO (>25 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	≥98% (TLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Culbert A.A., et al. (2001) FEBS Letters. 507(3): 288–294. 2. Coghlan M.P., et al. (2000) Chem. Biol. 7(10): 793–803.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900293-1	SIH-510-5MG	5 mg	$107		Add to Cart
BHB11900293-2	SIH-510-25MG	25 mg	$393		Add to Cart

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