Rottlerin

Mfr.No.	SIH-394
Alternative Names	3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
Appearance	Orange to brown solid.
Function	Autophagy inducer
Inchi	InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
Inchikey	DEZFNHCVIZBHBI-ZHACJKMWSA-N
Mode Of Action	Inducer
Molecular Formula	C30H28O8
Pubchem Cid	5281847
Sd File	C30H28O8 APtclcactv04251417312D 0 0.00000 0.00000 66 69 0 0 0 0 0 0 0 0999 V2000 4.6340 -3.2505 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5000 -4.7505 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7679 -3.7505 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6340 -5.2505 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7679 -4.7505 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5000 1.2495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8981 -0.2752 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3947 -1.1393 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5000 4.7136 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 3.8476 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.9631 -0.4405 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4221 2.6524 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8800 1.2495 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8100 3.5185 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8100 5.2505 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.2321 -0.7505 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3660 -0.2505 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3660 0.7495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2321 1.2495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0000 2.1155 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5000 -3.7505 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0000 2.1155 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5000 2.9815 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5000 2.9815 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0000 3.8476 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0000 3.8476 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0981 -2.2505 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 2.1155 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.5000 -0.7505 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.7321 2.1155 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.5000 1.2495 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.5000 2.9815 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.5000 4.7136 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.2321 -1.7505 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5000 2.9815 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0981 -0.2505 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0981 0.7495 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3660 -2.2505 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3660 -3.2505 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9920 -0.7852 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.9920 1.2841 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8981 0.7703 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8981 -0.2713 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.8291 -1.9405 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9848 1.9041 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8894 1.1418 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.9384 1.6879 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.9030 -3.5605 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4338 1.0824 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8957 -0.8952 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.5181 -0.2776 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9005 0.3448 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8566 -1.4472 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7027 -1.6774 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9329 -0.8314 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6340 -2.6305 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0369 -5.0605 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2310 -3.4405 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.6340 -5.8705 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.0369 4.4036 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.8100 5.2505 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9631 5.0236 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2310 -5.0605 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5369 4.1576 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6900 4.3845 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4631 3.5376 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 16 36 1 0 0 0 0 16 17 2 0 0 0 0 16 34 1 0 0 0 0 36 37 2 0 0 0 0 36 40 1 0 0 0 0 17 18 1 0 0 0 0 17 29 1 0 0 0 0 34 38 1 0 0 0 0 27 34 2 0 0 0 0 19 37 1 0 0 0 0 37 41 1 0 0 0 0 40 43 1 0 0 0 0 6 18 1 0 0 0 0 38 39 2 0 0 0 0 19 30 1 0 0 0 0 41 42 2 0 0 0 0 7 43 1 0 0 0 0 8 43 1 0 0 0 0 6 20 1 0 0 0 0 21 39 1 0 0 0 0 20 22 1 0 0 0 0 20 23 2 0 0 0 0 1 21 1 0 0 0 0 2 21 2 0 0 0 0 22 24 2 0 0 0 0 22 31 1 0 0 0 0 23 25 1 0 0 0 0 23 32 1 0 0 0 0 1 3 2 0 0 0 0 2 4 1 0 0 0 0 24 26 1 0 0 0 0 24 35 1 0 0 0 0 9 25 1 0 0 0 0 3 5 1 0 0 0 0 26 33 1 0 0 0 0 10 35 1 0 0 0 0 28 35 2 0 0 0 0 18 19 2 0 0 0 0 42 43 1 0 0 0 0 25 26 2 0 0 0 0 4 5 2 0 0 0 0 11 29 1 0 0 0 0 38 44 1 0 0 0 0 41 45 1 0 0 0 0 6 46 1 0 0 0 0 6 47 1 0 0 0 0 39 48 1 0 0 0 0 12 30 1 0 0 0 0 42 49 1 0 0 0 0 7 50 1 0 0 0 0 7 51 1 0 0 0 0 7 52 1 0 0 0 0 8 53 1 0 0 0 0 8 54 1 0 0 0 0 8 55 1 0 0 0 0 1 56 1 0 0 0 0 2 57 1 0 0 0 0 13 31 1 0 0 0 0 14 32 1 0 0 0 0 3 58 1 0 0 0 0 4 59 1 0 0 0 0 9 60 1 0 0 0 0 9 61 1 0 0 0 0 9 62 1 0 0 0 0 5 63 1 0 0 0 0 15 33 1 0 0 0 0 10 64 1 0 0 0 0 10 65 1 0 0 0 0 10 66 1 0 0 0 0 M END $$$$
Research Area	Cancer ; Autophagy
Safety Phrases	Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	C1=CC=CC=C1/C=C/C(C2=C(C(=C(C3=C2OC(C)(C)C=C3)O)CC4=C(C(=C(C(=C4O)C(C)=O)O)C)O)O)=O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	82-08-6
Molecular Weight	516.55
Scientific Background	Rottlerin has been shown to inhibit protein kinase C as well as CAM kinase III. It is also a potent activator of many K+ channels which are Ca2+-activated. Studies have illustrated Rottlerin to act as a mitochondrial uncoupler which depolarizes membrane potential. Lastly, Rottlerin can induce autophagy by inhibition of mTORC1 signalling.
Solubility	Soluble to 2 mM in ethanol and to 20 mM in DMSO.
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	≥98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Gschwendt M. et al. (1994) Biochem Biophys Res Commun. 199(1): 93-8. 2. Wu S., et al. (2007) J Cell Physiol. 210(3): 655-66. 3. Soltoff S. (2001) J Biol Chem. 276(41): 37986-92. 4. Balgi A., et al. (2009) PLoS One. 4(9): e7124.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900182-1	SIH-394-10MG	10 mg	$80		Add to Cart
BHB11900182-2	SIH-394-50MG	50 mg	$314		Add to Cart

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