PP1

Mfr.No.	SIH-469
Alternative Names	1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Appearance	Tan solid
Function	Src kinase inhibitor
Inchi	InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
Inchikey	ZVPDNRVYHLRXLX-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C16H19N5
Pubchem Cid	1400
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Acute toxicity, Oral (Category 3), H301 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant.
Smiles	CC1=CC=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C(C)(C)C
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	172889-26-8
Molecular Weight	281.4
Scientific Background	PP1 is a potent and selective Src family protein tyrosine kinase inhibitor. This has a range of effects and implications. Structural studies have revealed that PP1 binds to the ATP-binding site in tyrosine kinases and Ser/Thr kinases. PP1 displays > 8000-fold selectivity over ZAP-70 and JAK2.
Solubility	Soluble in DMSO (25 mg/ml), slightly soluble in 100% ethanol
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	≥ 98% (TLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Hanke J.H., et al. (1996) J. Biol. Chem. 271(2): 695–701. 2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900253-1	SIH-469-5MG	5 mg	$141		Add to Cart
BHB11900253-2	SIH-469-25MG	25 mg	$556		Add to Cart

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