PIN1 inhibitor API-1

Mfr.No.	T16538
Description	PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain and effectively inhibits Pin1 cis-trans isomerizing activity.
Molecular Formula	C15H13F3N6O2
Signaling Pathways	Others
Smiles	O(CC1=CC=C(CNC(C(F)(F)F)=O)C=C1)C2=C3C(N=CN3)=NC(N)=N2
Cas Number	680622-70-2
Molecular Weight	366.3
Target	Others

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SKU	Supplier No.	Size	Your price
BHB20409174	T16538	1 mL	$143	Add to Cart
BHB20409174	T16538	1 mg	$55	Add to Cart
BHB20409174	T16538	5 mg	$129	Add to Cart
BHB20409174	T16538	10 mg	$247	Add to Cart
BHB20409174	T16538	25 mg	$363	Add to Cart
BHB20409174	T16538	50 mg	$538	Add to Cart
BHB20409174	T16538	100 mg	$679	Add to Cart
BHB20409174	T16538	200 mg	$945	Add to Cart
BHB20409174	T16538	500 mg	$1380	Add to Cart