PHA 665752

Mfr.No.	SIH-421
Alternative Names	(2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine
Appearance	Yellow solid
Function	MET kinase inhibitor
Inchi	InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1
Inchikey	OYONTEXKYJZFHA-SSHUPFPWSA-N
Mode Of Action	Inhibitor
Molecular Formula	C32H34Cl2N4O4S
Pubchem Cid	10461815
Sd File	C32H34Cl2N4O4S APtclcactv04251417522D 0 0.00000 0.00000 77 82 0 0 1 0 0 0 0 0999 V2000 4.5981 -3.2313 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -2.7313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7321 -1.7313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -1.2313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -1.7313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -2.7313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -3.2313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -0.2313 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -1.2313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 -1.7313 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 4.9641 -2.5974 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9641 -0.8653 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.3301 -2.2313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 -1.7313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0622 -2.2313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0084 -1.9266 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.5920 -2.7313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.0084 -3.5361 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.0622 -3.2313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 -3.7313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3301 -3.2313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5920 -2.7313 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.3191 -0.9761 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2976 -0.7699 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7059 0.1430 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.7002 0.0367 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9064 -0.9418 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.0396 -1.4403 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 12.8193 -1.3501 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.3706 0.7787 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.0633 1.7303 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 13.3484 0.5691 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 14.0927 1.2369 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 13.5143 1.4601 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.9579 0.7354 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7483 -0.2423 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.7536 -0.3451 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.9899 2.2316 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.8000 2.8180 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 14.8017 3.8180 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.7533 4.1254 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 16.3397 3.3154 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 15.7505 2.5074 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2074 1.0099 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4631 -1.4213 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4631 -3.0413 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -3.8513 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9966 -0.7564 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.1995 -0.7564 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 -1.1113 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2010 -4.1254 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 -4.3513 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7932 -3.5413 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.9050 -0.5146 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9737 -2.0568 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.5661 -1.9161 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3852 -1.6033 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.0724 -0.7841 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.5472 0.5428 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2110 1.3014 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7472 -0.8623 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.3648 -0.3082 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.1636 -0.5357 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.8814 -0.9518 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7191 2.7894 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.3936 2.0618 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.6738 4.4247 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.1850 3.7543 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2907 4.4345 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.5021 4.6922 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 16.7997 2.8997 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 16.8011 3.7294 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.4973 1.9414 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 16.2869 2.1964 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7449 1.3189 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8983 1.5473 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6699 0.7008 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 0 0 0 0 2 3 2 0 0 0 0 3 4 1 0 0 0 0 4 5 2 0 0 0 0 5 6 1 0 0 0 0 6 7 2 0 0 0 0 2 7 1 0 0 0 0 4 8 1 0 0 0 0 3 9 1 0 0 0 0 9 10 1 0 0 0 0 10 11 2 0 0 0 0 10 12 2 0 0 0 0 10 13 1 0 0 0 0 13 14 1 0 0 0 0 14 15 2 0 0 0 0 15 16 1 0 0 0 0 16 17 1 0 0 0 0 17 18 1 0 0 0 0 18 19 1 0 0 0 0 15 19 1 0 0 0 0 19 20 2 0 0 0 0 20 21 1 0 0 0 0 13 21 2 0 0 0 0 17 22 2 0 0 0 0 16 23 2 0 0 0 0 23 24 1 0 0 0 0 24 25 2 0 0 0 0 25 26 1 0 0 0 0 26 27 2 0 0 0 0 27 28 1 0 0 0 0 24 28 1 0 0 0 0 27 29 1 0 0 0 0 26 30 1 0 0 0 0 30 31 2 0 0 0 0 30 32 1 0 0 0 0 32 33 1 0 0 0 0 33 34 1 0 0 0 0 33 35 1 0 0 0 0 35 36 1 0 0 0 0 36 37 1 0 0 0 0 32 37 1 0 0 0 0 33 38 1 1 0 0 0 38 39 1 0 0 0 0 39 40 1 0 0 0 0 40 41 1 0 0 0 0 41 42 1 0 0 0 0 42 43 1 0 0 0 0 39 43 1 0 0 0 0 25 44 1 0 0 0 0 5 45 1 0 0 0 0 6 46 1 0 0 0 0 7 47 1 0 0 0 0 9 48 1 0 0 0 0 9 49 1 0 0 0 0 14 50 1 0 0 0 0 18 51 1 0 0 0 0 20 52 1 0 0 0 0 21 53 1 0 0 0 0 23 54 1 0 0 0 0 28 55 1 0 0 0 0 29 56 1 0 0 0 0 29 57 1 0 0 0 0 29 58 1 0 0 0 0 35 59 1 0 0 0 0 35 60 1 0 0 0 0 36 61 1 0 0 0 0 36 62 1 0 0 0 0 37 63 1 0 0 0 0 37 64 1 0 0 0 0 38 65 1 0 0 0 0 38 66 1 0 0 0 0 40 67 1 0 0 0 0 40 68 1 0 0 0 0 41 69 1 0 0 0 0 41 70 1 0 0 0 0 42 71 1 0 0 0 0 42 72 1 0 0 0 0 43 73 1 0 0 0 0 43 74 1 0 0 0 0 44 75 1 0 0 0 0 44 76 1 0 0 0 0 44 77 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	ClC1=C(C(=CC=C1)Cl)C[S](=O)(=O)C3=CC=C2NC(C(/C2=C3)=CC4=C(C(=C([NH]4)C)C(=O)N5CCC[C@@H]5CN6CCCC6)C)=O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	477575-56-7
Molecular Weight	641.61
Scientific Background	PHA 665752 is a potent and selective MET kinase, ATP-competitive inhibitor. It has been studied as an antitumor agent because it has been seen to inhibit tumorigenicity and angiogenesis in mouse lung cancer xenografts.
Solubility	Soluble to 100 mM in DMSO.
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	>98
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Puri N., Khramtsov A., Ahmed S., Nallasura V., Hetzel J., Jagadeeswaran R., et al. (2007) Cancer Res. 3529-34.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900207-1	SIH-421-5MG	5 mg	$129		Add to Cart
BHB11900207-2	SIH-421-25MG	25 mg	$516		Add to Cart

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