P53R3

Mfr.No.	T41068
Description	P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53 R273H. This compound exhibits p53-dependent antiproliferative effects with significantly higher specificity compared to PRIMA-1 and promotes the recruitment of both wild-type p53 and p53 M237I to various target gene promoters. Additionally, P53R3 markedly increases the mRNA, total protein, and cell surface expression of death receptor 5 (DR5), demonstrating its utility in cancer research.
Molecular Formula	C32H35Cl2N5O2
Signaling Pathways	Apoptosis
Smiles	C(N1CCN(CC=2N=C(N(CH)(C(OC)=O)C(C)C)C3=C(N2)C=CC=C3)CC1)(C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5
Cas Number	922150-12-7
Molecular Weight	592.56
Target	p53

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SKU	Supplier No.	Size	Your price
BHB20428843	T41068	1 mg	$68	Add to Cart
BHB20428843	T41068	5 mg	$173	Add to Cart
BHB20428843	T41068	10 mg	$259	Add to Cart
BHB20428843	T41068	25 mg	$430	Add to Cart
BHB20428843	T41068	50 mg	$592	Add to Cart
BHB20428843	T41068	100 mg	$822	Add to Cart
BHB20428843	T41068	500 mg	$1630	Add to Cart