Nutlin-3

Mfr.No.	SIH-344
Alternative Names	(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5- ; dihydro-imidazole ; -1-carbonyl]-piperazin-2-one
Appearance	Yellow solid
Function	p53/mdm2 inhibitor
Inchi	InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)
Inchikey	BDUHCSBCVGXTJM-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C30H30Cl2N4O4
Pubchem Cid	216345
Research Area	Cancer ; Apoptosis ; Cancer Growth Inhibitors ; p53/mdm2 Inhibitors
Safety Phrases	Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Smiles	CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	548472-68-0
Molecular Weight	581.9
Scientific Background	MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
Solubility	Soluble in 100 mM DMSO and Ethanol
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Vassilev et al (2004) Science 303: 844.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900132-1	SIH-344-5MG	5 mg	$167		Add to Cart
BHB11900132-2	SIH-344-25MG	25 mg	$595		Add to Cart