NSC-66811

Mfr.No.	SIH-338
Alternative Names	2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol, 7-[Anilino(phenyl)methyl]-2-methylquinolin-8-ol
Appearance	White Solid
Function	p53/mdm2 inhibitor
Inchi	InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3
Inchikey	WEENRMPCSWFMTE-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C23H20N2O
Pubchem Cid	248986
Research Area	Cancer ; Apoptosis ; Cancer Growth Inhibitors ; p53/mdm2 Inhibitors
Safety Phrases	Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Smiles	CC1=NC2=C(C=C1)C=CC(=C2O)C(C3=CC=CC=C3)NC4=CC=CC=C4
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	6964-62-1
Molecular Weight	340.4
Scientific Background	A novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. Binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.
Solubility	Soluble in 25 mg/ml DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Lu Y., et al. (2006) J. Med.Chem. 49: 3759.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900126-1	SIH-338-10MG	10 mg	$145		Add to Cart
BHB11900126-2	SIH-338-50MG	50 mg	$595		Add to Cart