N,N-Dimethylsphingosine

Mfr.No.	SIH-235
Alternative Names	(2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol
Appearance	White to off-white waxy solid, or viscous oil
Function	Kinase inhibitor
Inchi	InChI=1S/C20H37NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(25)19(16-22)21(17-23)18-24/h14-15,17-20,22,25H,2-13,16H2,
Inchikey	XPDYLGZWYWKOFM-PPQGUHKJSA-N
Mode Of Action	Inducer
Molecular Formula	C20H41NO2
Pubchem Cid	6438166
Research Area	Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R20/21/22- Harmful by inhalation, in contact with skin and if swallowed
Smiles	CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)N(C)C)O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	119567-63-4
Molecular Weight	327.6
Scientific Background	N,N-dimethylsphingosine is a potent and specific inhibitor of sphingosine kinase. It is a natural metabolite of sphiongosine in some cancel cell lines and tissues (1). It also induces apoptosis, but it is not an inhibitor of protein kinase C (2).
Solubility	Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Yatomi Y., et al. (1996) Biochem. 35: 626-633. 2. Sweeny E.A., et al. (1996) Int J Cancer. 66(3): 358-366.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900059-1	SIH-235-5MG	5 mg	$68		Add to Cart
BHB11900059-2	SIH-235-25MG	25 mg	$276		Add to Cart