Milademetan HCl (1398568-47-2 free base)

Mfr.No.	T28038
Description	Milademetan is a potent and selective MDM2 inhibitor. MDM2 inhibitor DS-3032b binds to and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53 upon oral administration. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis.
Alternative Names	DS3032b
Molecular Formula	C30H35Cl3FN5O4
Signaling Pathways	Others
Smiles	O=C((CH)(N1)(CH)(C2=C(F)C(Cl)=NC=C2)(C)3(C(NC4=C3C=CC(Cl)=C4)=O)C51CCC(C)(C)CC5)N(CH)6CO(CH)(C(N)=O)CC6.(H)Cl
Molecular Weight	654.99
Target	Others

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SKU	Supplier No.	Size	Your price	Quantity
BHB20417891	T28038	100 mg	-		Add to Quote
BHB20417891	T28038	500 mg	-		Add to Quote