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Home / Biochemicals / Small Molecules

MAPKII Kinase Inhibitor

SKU : BHB11900011

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StressMarq Biosciences Inc.

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Mfr.No.	SIH-120
Appearance	White Solid
Function	Hsp25 Kinase Inhibitor
Mode Of Action	Inhibitor
Molecular Formula	C61H113N21O6
Research Area	Cancer ; Heat Shock
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Molecular Weight	1396.7
Scientific Background	The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). In particular, MAPKAP-kinase II (or otherwise known as MK2) is involved in inflammation, and is considered a target for therapeutic intervention for inflammation and cancer (3). MK2 is a member of the p38 MAPKinase pathway, and is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (3).
Solubility	Soluble in DMSO or H20
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.001
Purity	>95%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Pearson G. et al. (2001). Endocrine Reviews 22 (2): 153-183. 2. Fan Y., et al. (2007) Mol. Cells 23 (1): 30-38. 3. Deng et al. (2003) Cell 115: 61-70.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900011-1	SIH-120A	1 mg	$114		Add to Cart

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