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K-TMZ

SKU : BHB20425461

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Description
Review(s)

Mfr.No.	T36100
Description	K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 uM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 uM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.
Signaling Pathways	Others
Smiles	N/A
Target	Others

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SKU	Supplier No.	Size	Your price
BHB20425461	T36100	1 mg	$129	Add to Cart
BHB20425461	T36100	5 mg	$329	Add to Cart
BHB20425461	T36100	10 mg	$528	Add to Cart

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K-TMZ

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