IOX1

Mfr.No.	SIH-377
Alternative Names	8-Hydroxy-5-quinolinecarboxylic acid; (5-Carboxy-8HQ)
Appearance	Yellow powder
Function	JMJD inhibitor
Inchi	InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
Inchikey	JGRPKOGHYBAVMW-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C10H7NO3
Pubchem Cid	459617
Research Area	Cell Signaling ; Epigenetics and Nuclear Signaling
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	5852-78-8
Molecular Weight	189.2
Scientific Background	IOX1 is a cell permeable inhibitor of the JMJD family of 2-oxoglutarate-dependent histone demethylases (IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 M for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively1). It is a broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling (1).
Solubility	May be dissolved in DMSO (20 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. King O.N., et al. (2010) PLoS One. 5: e15535.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900165-1	SIH-377-5MG	5 mg	$91		Add to Cart
BHB11900165-2	SIH-377-25MG	25 mg	$381		Add to Cart