Herbimycin A

Mfr.No.	SIH-116
Alternative Names	[(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
Appearance	Yellow Solid
Function	Hsp90 inhibitor
Inchi	InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(
Inchikey	MCAHMSDENAOJFZ-BVXDHVRPSA-N
Mode Of Action	Inhibitor
Molecular Formula	C30H42N2O9
Pubchem Cid	6436247
Research Area	Cancer ; Heat Shock
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C=C([C@@H]1OC)C2=O)/C)OC)OC(=O)N)C)C)OC)OC
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	70563-58-5
Molecular Weight	574.3
Scientific Background	Herbimycin A, a benzoquinoid ansamycin antibiotic, irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups (1,2). It is effective on Src, Yes, Fps, Ros, Abl and ErbB oncogene products (1-3) and inhibits thrombin-induced tyrosine phosphorylation of phospholipase C (4). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
Solubility	Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.0001
Purity	>98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Uehara Y., and Fukazawa H. (1991) Methods Enzymol. 201: 370. 2. Fukazawa H., et al. (1991) Biochem. Pharmacol. 42: 1661. 3. Satoh T., et al. (1992) J.Biol.Chem. 267: 2537. 4. Weiss R., and Nuccitelli R. (1992) J.Biol.Chem. 267:5608.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900007-2	SIH-116B	1 mg	$923		Add to Cart
BHB11900007-1	SIH-116A	100 ug	$167		Add to Cart

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