Galanthamine HBr

Mfr.No.	SIH-530
Alternative Names	Galantamine hydrobromide, Galantamine HBr, Galanthamine hydrobromide, Galanthamine, Galanthamine hydrogen bromide, SPECTRUM1501202, 1,2,3,4,6,7,7a,11c-Octahydro-9-methoxy-2-methyl-benzofuro(4,3,2-efg)(2)benzazocin-6-ol HBr, LS-185021, Galanthamine, Nivalin, Reminyl, Jilkon hydrobromide, Lycoremine hydrobromide
Appearance	White powder
Function	Acetylcholinesterase inhibitor
Inchi	1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
Inchikey	QORVDGQLPPAFRS-XPSHAMGMSA-N
Mode Of Action	Inhibitor
Molecular Formula	C17H22BrNO3
Pubchem Cid	121587
Sd File	C17H22BrNO3 APtclcactv08241614413D 0 0.00000 0.00000 44 45 0 0 1 0 0 0 0 0999 V2000 3.2430 -1.0902 0.5154 C 0 0 1 0 0 0 0 0 0 0 0 0 2.5731 -0.5757 1.7917 C 0 0 2 0 0 0 0 0 0 0 0 0 0.3795 -1.6569 1.1488 C 0 0 1 0 0 0 0 0 0 0 0 0 18.5815 -0.4514 0.5861 H 0 3 0 0 0 0 0 0 0 0 0 0 3.3079 -0.5634 2.5967 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0906 -1.4726 1.5089 H 0 0 0 0 0 0 0 0 0 0 0 0 4.0057 -2.8701 1.4081 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7527 -2.3451 2.6250 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8943 -0.8600 3.0563 H 0 0 0 0 0 0 0 0 0 0 0 0 2.6451 -2.0449 -1.3854 H 0 0 0 0 0 0 0 0 0 0 0 0 5.6694 -3.4048 -0.0846 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4024 -2.7404 -1.1204 H 0 0 0 0 0 0 0 0 0 0 0 0 -0.2621 -2.4841 1.4524 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9568 -1.0996 -2.5883 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3454 -0.0391 -2.2901 H 0 0 0 0 0 0 0 0 0 0 0 0 0.4477 -2.4973 -0.9031 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4181 1.9586 -2.3965 H 0 0 0 0 0 0 0 0 0 0 0 0 4.2614 3.7866 -1.3014 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8877 -2.9035 -2.2816 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7276 -2.8329 -0.7138 H 0 0 0 0 0 0 0 0 0 0 0 0 7.9216 -1.5091 -1.8879 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5651 4.9685 -0.8029 H 0 0 0 0 0 0 0 0 0 0 0 0 3.9216 5.1216 0.3392 H 0 0 0 0 0 0 0 0 0 0 0 0 2.2864 5.6283 0.8266 H 0 0 0 0 0 0 0 0 0 0 0 0 4.7668 1.7427 -1.5625 C 0 0 0 0 0 0 0 0 0 0 0 0 4.1032 2.7780 -0.9492 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2265 -2.2443 -1.4823 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8576 4.9046 0.2451 C 0 0 0 0 0 0 0 0 0 0 0 0 3.2338 2.5600 0.1126 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.0978 -0.5816 0.2755 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3943 -2.0091 0.8643 C 0 0 0 0 0 0 0 0 0 0 0 0 1.3918 -1.3898 2.2440 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1318 -2.4941 -0.3488 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5238 -0.5775 -1.8176 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.4235 -0.4896 0.9625 O 0 0 0 0 0 0 0 0 0 0 0 0 2.5950 3.5876 0.7336 O 0 0 0 0 0 0 0 0 0 0 0 0 3.0474 1.2312 0.5122 C 0 0 0 0 0 0 0 0 0 0 0 0 4.6226 0.4111 -1.1368 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2120 0.7745 1.4715 O 0 0 0 0 0 0 0 0 0 0 0 0 2.2776 -1.7531 -0.4127 C 0 0 0 0 0 0 0 0 0 0 0 0 1.0406 -2.0055 -0.1461 C 0 0 0 0 0 0 0 0 0 0 0 0 -12.1269 -0.0895 -0.3560 Br 0 5 0 0 0 0 0 0 0 0 0 0 6.0710 -1.5536 -0.8944 N 0 0 0 0 0 0 0 0 0 0 0 0 3.7399 0.1924 -0.1274 C 0 0 0 0 0 0 0 0 0 0 0 0 2 39 1 0 0 0 0 37 39 1 0 0 0 0 3 35 1 0 0 0 0 30 35 1 0 0 0 0 29 36 1 0 0 0 0 28 36 1 0 0 0 0 33 43 1 0 0 0 0 34 43 1 0 0 0 0 27 43 1 0 0 0 0 1 2 1 0 0 0 0 1 44 1 0 0 0 0 1 31 1 0 0 0 0 1 40 1 0 0 0 0 2 32 1 0 0 0 0 2 5 1 0 0 0 0 37 44 1 0 0 0 0 38 44 2 0 0 0 0 31 33 1 0 0 0 0 6 31 1 0 0 0 0 7 31 1 0 0 0 0 3 32 1 0 0 0 0 8 32 1 0 0 0 0 9 32 1 0 0 0 0 40 41 2 0 0 0 0 10 40 1 0 0 0 0 29 37 2 0 0 0 0 11 33 1 0 0 0 0 12 33 1 0 0 0 0 34 38 1 0 0 0 0 25 38 1 0 0 0 0 3 41 1 0 0 0 0 3 13 1 0 0 0 0 14 34 1 0 0 0 0 15 34 1 0 0 0 0 16 41 1 0 0 0 0 26 29 1 0 0 0 0 25 26 2 0 0 0 0 17 25 1 0 0 0 0 18 26 1 0 0 0 0 19 27 1 0 0 0 0 20 27 1 0 0 0 0 21 27 1 0 0 0 0 22 28 1 0 0 0 0 23 28 1 0 0 0 0 24 28 1 0 0 0 0 M CHG 2 4 1 42 -1 M END $$$$
Research Area	Neuroscience ; Neurodegeneration ; Alzheimer's Disease ; Cancer ; Apoptosis
Safety Phrases	Classification: D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion Hazard statement(s): H301 Toxic if swallowed. Precautionary statement(s): P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
Smiles	[Br-].COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24.[H+]
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	1953-04-4
Molecular Weight	368.3
Scientific Background	Galantamine hydrobromide is a long-acting, active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. It prevents β-amyloid-induced apoptosis in SH-SY5Y. Long-term administration in a mouse model of Alzheimer's disease reduces amyloid precursor protein deposition and neurodegeneration in these mice.
Solubility	Soluble in water (12 mg/ml) or in DMSO (10 mg/ml)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Blue Ice or 4ºC
Gross Weight (kg)	0.25
Net Weight (g)	0.1
Purity	>97% (HPLC); NMR (Conforms)
Storage Temperature	-20ºC
Stock Product	Y

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BHB11900311-2	SIH-530-100MG	100 mg	$141		Add to Cart

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