EN6

Mfr.No.	T11191
Description	EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative agent in frontotemporal dementia, in a lysosome-dependent manner. EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).
Molecular Formula	C19H14F2N4O2
Signaling Pathways	Membrane transporter/Ion channel, Autophagy
Smiles	FC1=C(N2C=C(C(NC3=CC(NC(C=C)=O)=C(F)C=C3)=O)C=N2)C=CC=C1
Cas Number	1808714-73-9
Molecular Weight	368.34
Target	Proton pump, Autophagy

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SKU	Supplier No.	Size	Your price
BHB20401901	T11191	1 mL	$64	Add to Cart
BHB20401901	T11191	1 mg	$39	Add to Cart
BHB20401901	T11191	5 mg	$80	Add to Cart
BHB20401901	T11191	10 mg	$139	Add to Cart
BHB20401901	T11191	25 mg	$216	Add to Cart
BHB20401901	T11191	50 mg	$278	Add to Cart
BHB20401901	T11191	100 mg	$422	Add to Cart
BHB20401901	T11191	500 mg	$957	Add to Cart