Doxorubicin Hydrochloride

Mfr.No.	SIH-390
Alternative Names	Adriamycin
Appearance	Red solid
Function	Autophagy inducer
Inchi	InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
Inchikey	MWWSFMDVAYGXBV-RUELKSSGSA-N
Mode Of Action	Inducer
Molecular Formula	C27H29NO11•HCl
Pubchem Cid	443939
Sd File	C27H30ClNO11 APtclcactv04251417282D 0 0.00000 0.00000 70 72 0 0 1 0 0 0 0 0999 V2000 3.9928 5.8936 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 3.0867 4.3381 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 4.9147 0.0000 0.0000 H 0 3 0 0 0 0 0 0 0 0 0 0 3.4589 6.2087 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8777 5.9634 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.4759 5.2736 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.5992 3.3452 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3974 3.3545 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6847 7.7073 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7650 8.2887 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.3745 8.9835 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7622 9.2296 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8833 8.1197 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4051 6.8036 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2367 7.4740 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.6298 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.8443 6.3931 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4848 2.8553 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.1735 3.2565 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3428 3.1612 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8295 5.7135 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8295 4.0043 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5148 6.9132 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.7319 7.7627 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8824 7.9799 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3499 3.7812 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2937 5.4014 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.2937 4.3164 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5901 3.4663 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.5405 6.9336 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.1986 7.4466 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7528 5.8589 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.7528 3.8589 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.3499 5.9366 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.9021 2.9344 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.8476 10.2171 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7738 10.2295 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.0231 8.6297 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.2897 7.1689 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.2158 2.5489 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 0.2822 2.9243 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0867 5.3797 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.9928 3.8243 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1557 8.4034 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5834 5.1983 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.5012 6.8935 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.5012 2.8243 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.0867 4.3342 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5901 3.4702 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.5636 8.9334 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.7528 6.8589 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.7528 2.8589 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.5901 3.4624 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.0044 6.8935 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 9.3384 6.9366 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9147 0.0000 0.0000 Cl 0 5 0 0 0 0 0 0 0 0 0 0 4.8867 5.3589 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8867 4.3589 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6188 5.3589 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6188 4.3589 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4188 5.3797 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.4188 4.3381 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5127 5.8936 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.5127 3.8243 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.1442 7.4035 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.2955 8.9134 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4238 8.4234 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.4122 7.4235 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3071 9.9133 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.2724 6.9135 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 54 1 6 0 0 0 54 65 1 0 0 0 0 65 70 1 0 0 0 0 68 70 1 0 0 0 0 2 49 1 6 0 0 0 35 49 1 0 0 0 0 50 67 1 0 0 0 0 38 50 1 0 0 0 0 32 51 1 0 0 0 0 39 51 1 0 0 0 0 33 52 1 0 0 0 0 40 52 1 0 0 0 0 45 48 2 0 0 0 0 29 53 1 0 0 0 0 41 53 1 0 0 0 0 46 63 2 0 0 0 0 47 64 2 0 0 0 0 34 55 1 0 0 0 0 31 55 1 0 0 0 0 66 69 1 0 0 0 0 36 69 1 0 0 0 0 37 69 1 0 0 0 0 1 42 1 0 0 0 0 1 57 1 0 0 0 0 1 4 1 0 0 0 0 2 42 1 0 0 0 0 2 43 1 0 0 0 0 2 48 1 0 0 0 0 5 42 1 0 0 0 0 6 42 1 0 0 0 0 43 58 1 0 0 0 0 7 43 1 0 0 0 0 8 43 1 0 0 0 0 57 58 2 0 0 0 0 32 57 1 0 0 0 0 33 58 1 0 0 0 0 44 65 1 0 0 0 0 9 65 1 0 0 0 0 44 66 1 0 0 0 0 10 44 1 0 0 0 0 11 44 1 0 0 0 0 66 67 1 0 0 0 0 12 66 1 0 0 0 0 67 68 1 0 0 0 0 13 67 1 0 0 0 0 30 68 1 0 0 0 0 14 68 1 0 0 0 0 32 59 2 0 0 0 0 29 48 1 0 0 0 0 33 60 2 0 0 0 0 59 60 1 0 0 0 0 59 63 1 0 0 0 0 60 64 1 0 0 0 0 15 30 1 0 0 0 0 16 30 1 0 0 0 0 17 30 1 0 0 0 0 18 29 1 0 0 0 0 19 29 1 0 0 0 0 61 63 1 0 0 0 0 62 64 1 0 0 0 0 61 62 2 0 0 0 0 34 61 1 0 0 0 0 26 62 1 0 0 0 0 27 34 2 0 0 0 0 26 28 2 0 0 0 0 20 26 1 0 0 0 0 27 28 1 0 0 0 0 21 27 1 0 0 0 0 22 28 1 0 0 0 0 23 31 1 0 0 0 0 24 31 1 0 0 0 0 25 31 1 0 0 0 0 M CHG 2 3 1 56 -1 M END $$$$
Research Area	Cancer ; Autophagy
Safety Phrases	Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H350- May cause cancer. Precautionary statements: P201- Obtain special instructions before use. P308 + P313- IF exposed or concerned: Get medical advice/ attention.
Smiles	[C@H]2(OC1OC(C(O)C(N)C1)C)C[C@@](O)(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)C(=O)CO.[H+].[Cl-]
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	25316-40-9
Molecular Weight	580
Scientific Background	Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefore induces apoptosis by hindering cellular functions like replication and transcription by specifically inhibiting the binding of reverse transcriptase, RNA polymerase and topoisomerase II. Doxorubicin has some adverse effects for patients including immunosuppressive effects caused by hematologic toxicity. Doxorubicin has also been shown to induce autophagy in a species-specific manner.
Solubility	Soluble in water (50 mM).
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	>98% (TLC); NMR (Conforms)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Kusayanagi, T. et al. (2012). Bioorg Med Chem. 20(21): 6248-55. 2. Chen, N. T. et al. (2012). PLoS One. 7(9). 3. Patel, S. et al. (1997). Mol Pharmacol. 52(4): 658-66. 4. Cutts, S. et al. (1996). J Biol Chem. 271(10): 5422-9. 5. Danesi, R. et al. (2004). Transplant Proc. 36(3): 703-4. 6. Dirks-Naylor, A. (2013). Life Sci. 93(24): 913-6.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900178-1	SIH-390-10MG	10 mg	$129		Add to Cart
BHB11900178-2	SIH-390-50MG	50 mg	$465		Add to Cart

Doxorubicin Hydrochloride

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