CCT241161

Mfr.No.	SIH-186
Alternative Names	1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-(methylthio)-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea
Appearance	White Solid
Function	RAF Inhibitor
Mode Of Action	Inhibitor
Molecular Formula	C28H27N7O3S
Research Area	Cancer ; Apoptosis
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Smiles	CC(C)(C)C1=NN(C2=CC=CC=C2)C(NC(NC(C(SC)=C3)=CC=C3OC4=C5C(NC(C=N5)=O)=NC=C4)=O)=C1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	1163719-91-2
Molecular Weight	541.63
Scientific Background	CCT241161, a pan-RAF/SFK inhibitor is active against treatment-naive BRAF and NRAS mutant tumors. It is active in tumors from patients who developed resistance to BRAF-selective inhibitors and a BRAF plus MEK inhibitor combination. IC50 0.03µM and 0.01µM for BRAF kinase and SRC kinase respectively.
Solubility	Soluble in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Girotti, M.R., et al. (2015) Cancer Cell 27.1: 85-96.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900028-1	SIH-186-10MG	10 mg	$628		Add to Cart